Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.56 |
| ▸ | AURKA | O14965 | 4/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 4/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | BCL3 | P20749 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4308978 | 1.00 | AURKB (0.56) | AURKBAURKAHDAC1PDGFRBPDGFRA | |
| SCHEMBL4319792 | 0.94 | AURKA (0.51) | AURKBAURKAHDAC1PDGFRBPDGFRA | |
| SCHEMBL4319796 | 0.94 | AURKA (0.51) | AURKBAURKAHDAC1PDGFRBPDGFRA | |
| SCHEMBL4309030 | 0.89 | AURKA (0.51) | AURKBAURKAHDAC1KDRMAPK14 | |
| SCHEMBL4309036 | 0.89 | AURKA (0.51) | AURKBAURKAHDAC1KDRMAPK14 | |
| SCHEMBL14989354 | 0.88 | AURKB (0.70) | AURKBAURKAFGFR1MAPK14FLT3 | |
| SCHEMBL14989352 | 0.88 | AURKB (0.70) | AURKBAURKAFGFR1MAPK14FLT3 | |
| SCHEMBL4319811 | 0.87 | AURKA (0.55) | AURKBAURKAKDRFGFR1FLT3 | |
| SCHEMBL4319807 | 0.87 | AURKA (0.55) | AURKBAURKAKDRFGFR1FLT3 | |
| SCHEMBL14989033 | 0.86 | AURKB (0.72) | AURKBAURKAMAPK14FLT3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605272-B2 | IGF-1R inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090054508-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1847532-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054508-A1 | IGF-1R INHIBITOR | IGF1R, IGFBP5, IGFBP1 | AURKB 3438/4885AURKA 3687/4885HDAC1 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.