Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.51 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.51 |
| ▸ | PDE5A | O76074 | 17/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10083045 | 0.90 | KCNH2 (0.79) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL431126 | 0.89 | ADORA3 (0.62) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| Sulfuric Acid SCHEMBL428371 | 0.88 | ADORA3 (0.61) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL173886 | 0.88 | ADORA3 (0.64) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL430664 | 0.88 | KCNH2 (0.65) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| Hydrochloric Acid SCHEMBL427311 | 0.87 | ADORA3 (0.63) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL430662 | 0.86 | ADORA3 (0.58) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL14852804 | 0.85 | GUCY1A1 (0.52) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| Phosphoric Acid SCHEMBL430663 | 0.85 | ADORA3 (0.61) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| Maleic Acid SCHEMBL427303 | 0.84 | ADORA3 (0.60) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9266885-B2 | Substituted 5-fluoro-1H-pyrazolopyridines and their use | ADVERIO PHARMA GMBH (DE) | 2016-02-23 | — | — | US | claimed |
| US-20150080414-A1 | SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-19 | — | — | US | claimed |
| US-8921377-B2 | Substituted 5-fluoro-1H-pyrazolopyridines and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-12-30 | — | — | US | claimed |
| US-20120022084-A1 | Substituted 5-fluoro-1H-pyrazolopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-26 | — | — | US | claimed |
| US-9266885-B2 | Substituted 5-fluoro-1H-pyrazolopyridines and their use | ADVERIO PHARMA GMBH (DE) | 2016-02-23 | — | — | US | disclosed |
| US-20150080414-A1 | SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-19 | — | — | US | disclosed |
| US-8921377-B2 | Substituted 5-fluoro-1H-pyrazolopyridines and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-12-30 | — | — | US | disclosed |
| US-20130237551-A1 | Substituted 5-fluoro-1H-pyrazolopyridines and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-09-12 | — | — | US | disclosed |
| US-20120022084-A1 | Substituted 5-fluoro-1H-pyrazolopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150080414-A1 | SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE | PFKP, PON1, FABP3 | ADORA3 1633/4885KCNH2 128/4885GUCY1A1 1337/4885 |
| US-20130237551-A1 | Substituted 5-fluoro-1H-pyrazolopyridines and their use | PFKP, PON1, FABP3 | ADORA3 1633/4885KCNH2 128/4885GUCY1A1 1337/4885 |
| US-20120022084-A1 | Substituted 5-fluoro-1H-pyrazolopyridines and their use | PFKP, PON1, FABP3 | ADORA3 1633/4885KCNH2 128/4885GUCY1A1 1337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.