Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4311120 | 0.86 | BRAF (0.52) | BRAFLMNARAB9AALDH1A1RAF1 | |
| SCHEMBL4318196 | 0.84 | CSF1R (0.66) | CSF1RAURKBKCNK3KCNK9MAPT | |
| SCHEMBL3475138 | 0.84 | CSF1R (0.71) | CSF1RKCNK3KCNK9MEN1KMT2A | |
| SCHEMBL3475141 | 0.84 | CSF1R (0.71) | CSF1RKCNK3KCNK9MEN1KMT2A | |
| SCHEMBL17937457 | 0.83 | CSF1R (0.47) | BRAFCSF1RKCNK3KCNK9MAPT | |
| SCHEMBL13340396 | 0.78 | CSF1R (0.70) | CSF1RKCNK3KCNK9MEN1KMT2A | |
| SCHEMBL13340329 | 0.75 | CSF1R (0.66) | CSF1RKCNK3KCNK9MAPTNPSR1 | |
| SCHEMBL17954640 | 0.73 | CSF1R (0.73) | CSF1RPTGS1DDR1 | |
| SCHEMBL4323640 | 0.72 | CSF1R (0.66) | BRAFCSF1RKCNK3KCNK9MEN1 | |
| SCHEMBL28024743 | 0.72 | MAPT (0.76) | KCNK3KCNK9MAPTNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099774-A1 | INHIBITORS OF KINASE ACTIVITY | Cytopia Research Pty Ltd (AU) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008058341-A1 | INHIBITORS OF KINASE ACTIVITY | CYTOPIA RESEARCH PTY LTD (AU) | 2008-05-22 | — | — | WO | disclosed |