SCHEMBL4318196

SCHEMBL4318196

O=C(Nc1cccc(CCNc2cncc(Cl)n2)c1)c1cccc(C(F)(F)F)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 5/20 0.66
KCNQ3 O43525 2/20 0.53
KCNQ2 O43526 2/20 0.53
KCNE1 P15382 2/20 0.53
KCNQ1 P51787 2/20 0.53
KCNQ5 Q9NR82 1/20 0.52
KCNK3 O14649 2/20 0.50
MAPT P10636 2/20 0.50
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
TSHR P16473 2/20 0.49
LMNA P02545 2/20 0.49
DDR1 Q08345 2/20 0.49
RET P07949 1/20 0.49
PDGFRB P09619 1/20 0.49
KIT P10721 1/20 0.49
SRC P12931 1/20 0.49
PDGFRA P16234 1/20 0.49
FLT1 P17948 1/20 0.49
FLT4 P35916 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13340329 0.91 CSF1R (0.66) CSF1RKCNQ3KCNQ2KCNE1KCNQ1
SCHEMBL4323640 0.86 CSF1R (0.66) CSF1RKCNK3MEN1KMT2ADDR1
SCHEMBL4312554 0.84 BRAF (0.51) CSF1RKCNK3MAPTMEN1KMT2A
SCHEMBL4324513 0.82 CSF1R (0.66) CSF1RDDR1RETPDGFRBKIT
SCHEMBL27167178 0.80 CSF1R (0.67) CSF1RMEN1KMT2ALMNADDR1
SCHEMBL4317671 0.80 CSF1R (0.53) CSF1RKCNQ3KCNQ2MAPTDDR1
SCHEMBL4311120 0.80 BRAF (0.52) LMNASRCKDRRAB9AALDH1A1
SCHEMBL3475948 0.80 CSF1R (1.00) CSF1RKCNQ3KCNQ2KCNE1KCNQ1
SCHEMBL3475951 0.80 CSF1R (1.00) CSF1RKCNQ3KCNQ2KCNE1KCNQ1
SCHEMBL13340366 0.80 CSF1R (1.00) CSF1RKCNQ3KCNQ2KCNE1KCNQ1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2099774-A1 INHIBITORS OF KINASE ACTIVITY Cytopia Research Pty Ltd (AU) 2009-09-16 EP disclosed
WO-2008058341-A1 INHIBITORS OF KINASE ACTIVITY CYTOPIA RESEARCH PTY LTD (AU) 2008-05-22 WO disclosed