SCHEMBL431263

SCHEMBL431263

CC(C)(C)OC(=O)N1CC(Oc2nc(F)c(Cl)cc2NC(=O)c2ccnc(Cl)c2)C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.37
HDAC2 Q92769 1/20 0.37
TAS1R3 Q7RTX0 2/20 0.37
TAS1R1 Q7RTX1 2/20 0.37
TAS1R2 Q8TE23 2/20 0.37
USP30 Q70CQ3 1/20 0.37
PTGES O14684 1/20 0.36
ANO1 Q5XXA6 1/20 0.36
PIK3CD O00329 3/20 0.36
TOP2A P11388 1/20 0.35
GPBAR1 Q8TDU6 1/20 0.35
CACNB4 O00305 1/20 0.35
CACNA1A O00555 1/20 0.35
CACNA1G O43497 1/20 0.35
CACNG3 O60359 1/20 0.35
CACNA1F O60840 1/20 0.35
CACNA1H O95180 1/20 0.35
CACNB3 P54284 1/20 0.35
CACNA2D1 P54289 1/20 0.35
CACNG7 P62955 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL432002 0.92 TAS1R3 (0.38) TAS1R3TAS1R1TAS1R2PTGESANO1
SCHEMBL433484 0.90 HDAC1 (0.37) HDAC1HDAC2TAS1R3TAS1R1TAS1R2
SCHEMBL432424 0.88 PIK3CD (0.39) TAS1R3TAS1R1TAS1R2USP30ANO1
SCHEMBL432167 0.86 TRPV1 (0.40) TAS1R3TAS1R1TAS1R2USP30PTGES
SCHEMBL432998 0.86 TAS1R3 (0.39) HDAC1HDAC2TAS1R3TAS1R1TAS1R2
SCHEMBL433153 0.86 ANO1 (0.39) TAS1R3TAS1R1TAS1R2USP30ANO1
SCHEMBL434448 0.77 HDAC2 (0.40) HDAC1HDAC2TAS1R3TAS1R1TAS1R2
SCHEMBL431257 0.77 MCHR1 (0.34) GSK3AGSK3BSCN9A
SCHEMBL431256 0.77 MCHR1 (0.34) GSK3AGSK3BSCN9A
SCHEMBL432425 0.74 HDAC2 (0.39) HDAC2TAS1R3TAS1R1TAS1R2GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012012366-A1 PESTICIDAL 3-(ARYLOXY)AZACYCLOALKANES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2012-01-26 WO disclosed