SCHEMBL434448

SCHEMBL434448

CC(C)COC(=O)N1CC(Oc2nc(N)c(Cl)cc2NC(=O)c2ccnc(Cl)c2)C1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 1/20 0.40
GPR119 Q8TDV5 1/20 0.35
CSNK1D P48730 1/20 0.34
CSNK1E P49674 1/20 0.34
PREP P48147 1/20 0.34
FAP Q12884 1/20 0.34
AAK1 Q2M2I8 1/20 0.34
TAS1R3 Q7RTX0 2/20 0.34
TAS1R1 Q7RTX1 2/20 0.34
TAS1R2 Q8TE23 2/20 0.34
HDAC1 Q13547 1/20 0.33
MALT1 Q9UDY8 1/20 0.33
RAF1 P04049 1/20 0.33
CA12 O43570 2/20 0.33
CA9 Q16790 2/20 0.33
MAP3K5 Q99683 1/20 0.33
MAPK14 Q16539 1/20 0.33
KIT P10721 1/20 0.33
ACACB O00763 1/20 0.32
PDE4D Q08499 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL432425 0.88 HDAC2 (0.39) HDAC2GPR119CSNK1DCSNK1EPREP
SCHEMBL433103 0.87 HDAC2 (0.39) HDAC2GPR119CSNK1DCSNK1EPREP
SCHEMBL433484 0.87 HDAC1 (0.37) HDAC2TAS1R3TAS1R1TAS1R2HDAC1
SCHEMBL433154 0.86 HDAC2 (0.39) HDAC2PREPFAPTAS1R3TAS1R1
SCHEMBL432002 0.79 TAS1R3 (0.38) GPR119TAS1R3TAS1R1TAS1R2
SCHEMBL435039 0.77 MCHR1 (0.34) CA12CA9
SCHEMBL435038 0.77 MCHR1 (0.34) CA12CA9
SCHEMBL431263 0.77 HDAC1 (0.37) HDAC2TAS1R3TAS1R1TAS1R2HDAC1
SCHEMBL432998 0.74 TAS1R3 (0.39) HDAC2TAS1R3TAS1R1TAS1R2HDAC1
SCHEMBL432424 0.74 PIK3CD (0.39) GPR119TAS1R3TAS1R1TAS1R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012012366-A1 PESTICIDAL 3-(ARYLOXY)AZACYCLOALKANES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2012-01-26 WO disclosed