Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | BUB1 | O43683 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13881869 | 1.00 | CETP (0.43) | CETPBUB1SUCNR1ALDH1A1TP53 | |
| SCHEMBL13881872 | 0.84 | CETP (0.42) | CETPSUCNR1RIPK1VNN1BDKRB1 | |
| SCHEMBL4308966 | 0.84 | CETP (0.42) | CETPSUCNR1RIPK1VNN1BDKRB1 | |
| SCHEMBL5517336 | 0.83 | P2RX7 (0.43) | CETPSUCNR1TP53RIPK1HPGD | |
| SCHEMBL5509355 | 0.83 | P2RX7 (0.43) | CETPSUCNR1TP53RIPK1HPGD | |
| SCHEMBL582729 | 0.83 | P2RX7 (0.43) | CETPSUCNR1TP53RIPK1HPGD | |
| SCHEMBL13881859 | 0.83 | CETP (0.41) | CETPSUCNR1RIPK1VNN1P2RX7 | |
| SCHEMBL4306551 | 0.83 | CETP (0.41) | CETPSUCNR1RIPK1VNN1P2RX7 | |
| SCHEMBL5517353 | 0.79 | KMT2A (0.46) | CETPSUCNR1ALDH1A1TP53RIPK1 | |
| SCHEMBL5513992 | 0.79 | KMT2A (0.46) | CETPSUCNR1ALDH1A1TP53RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090088458-A1 | N-(Pyridin-4-Yl)-2-Phenylbutanamides as Androgen Receptor Modulators | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | claimed |
| EP-1912945-A1 | N-(PYRIDIN-4-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2008-04-23 | — | — | EP | claimed |
| WO-2007016358-A1 | N-(PYRIDIN-4-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2007-02-08 | — | — | WO | claimed |
| US-20090088458-A1 | N-(Pyridin-4-Yl)-2-Phenylbutanamides as Androgen Receptor Modulators | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| EP-1912945-A1 | N-(PYRIDIN-4-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007016358-A1 | N-(PYRIDIN-4-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088458-A1 | N-(Pyridin-4-Yl)-2-Phenylbutanamides as Androgen Receptor Modulators | SHBG, AR, NR5A1 | CETP 3677/4885BUB1 2281/4885SUCNR1 1972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.