Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.46 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4314485 | 1.00 | KDR (0.55) | KDRFGFR1LCKCHEK1MAP2K4 | |
| SCHEMBL4315173 | 0.88 | KDR (0.59) | KDRFGFR1LCKCHEK1JAK2 | |
| SCHEMBL4315179 | 0.88 | KDR (0.59) | KDRFGFR1LCKCHEK1JAK2 | |
| SCHEMBL4310361 | 0.87 | KDR (0.45) | KDRCHEK1MAPK1 | |
| SCHEMBL4321084 | 0.87 | L3MBTL1 (0.51) | KDRCHEK1MAPK1 | |
| SCHEMBL4310371 | 0.87 | KDR (0.45) | KDRCHEK1MAPK1 | |
| SCHEMBL4321072 | 0.87 | L3MBTL1 (0.51) | KDRCHEK1MAPK1 | |
| SCHEMBL4319025 | 0.85 | FGFR1 (0.43) | KDRFGFR1LCKCHEK1MAP2K4 | |
| SCHEMBL4319021 | 0.85 | FGFR1 (0.43) | KDRFGFR1LCKCHEK1MAP2K4 | |
| SCHEMBL4314052 | 0.85 | AURKA (0.57) | KDRFGFR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605272-B2 | IGF-1R inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090054508-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1847532-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054508-A1 | IGF-1R INHIBITOR | IGF1R, IGFBP5, IGFBP1 | KDR 75/4885FGFR1 18/4885LCK 2277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.