Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15301452 | 1.00 | ACHE (0.39) | ACHECYP19A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL431489 | 1.00 | ACHE (0.39) | ACHECYP19A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL10049634 | 1.00 | ACHE (0.39) | ACHECYP19A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL15301451 | 1.00 | ACHE (0.39) | ACHECYP19A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9280385 | 0.83 | CA12 (0.39) | ACHESMN1; SMN2ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9280387 | 0.83 | CA12 (0.39) | ACHESMN1; SMN2ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9280381 | 0.83 | CA12 (0.39) | ACHESMN1; SMN2ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL30865768 | 0.79 | CA1 (0.53) | SMN1; SMN2ALDH1A1CA1CA2CA12 | |
| SCHEMBL10615596 | 0.75 | CA1 (0.48) | SMN1; SMN2ALDH1A1MAPTCA1CA2 | |
| SCHEMBL10615554 | 0.75 | CA1 (0.48) | SMN1; SMN2ALDH1A1MAPTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10434197-B2 | Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes | UNIVERSITY OF DELAWARE (US) | 2019-10-08 | — | — | US | disclosed |
| EP-2595967-B1 | TETRAZINE-TRANS-CYCLOOCTENE LIGATION FOR THE RAPID CONSTRUCTION OF RADIONUCLIDE LABELED PROBES | UNIV DELAWARE (US) | 2016-03-23 | — | — | EP | disclosed |
| US-20130266512-A1 | Tetrazine-trans-cyclooctene Ligation for the Rapid Construction of Radionuclide Labeled Probes | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2013-10-10 | — | — | US | disclosed |
| EP-2595967-A2 | TETRAZINE-TRANS-CYCLOOCTENE LIGATION FOR THE RAPID CONSTRUCTION OF RADIONUCLIDE LABELED PROBES | University Of Delaware (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012612-A2 | TETRAZINE-TRANS-CYCLOOCTENE LIGATION FOR THE RAPID CONSTRUCTION OF RADIONUCLIDE LABELED PROBES | UNIVERSITY OF DELAWARE (US) | 2012-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10434197-B2 | Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes | TTL, TALDO1, TTI1 | ACHE 2003/4885CYP19A1 117/4885SMN1; SMN2 4439/4885 |
| US-20130266512-A1 | Tetrazine-trans-cyclooctene Ligation for the Rapid Construction of Radionuclide Labeled Probes | TTL, TALDO1, TTI1 | ACHE 2003/4885CYP19A1 117/4885SMN1; SMN2 4439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.