Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9280387 | 1.00 | CA12 (0.39) | CA12CA1CA9CYP2D6CYP1A2 | |
| SCHEMBL9280381 | 1.00 | CA12 (0.39) | CA12CA1CA9CYP2D6CYP1A2 | |
| SCHEMBL7215095 | 0.90 | ALDH1A1 (0.43) | CA12CA1CA9CYP2D6CYP1A2 | |
| SCHEMBL11171926 | 0.89 | ALDH1A1 (0.45) | CA12CA1CA9CYP2D6CYP1A2 | |
| SCHEMBL499873 | 0.87 | CYP2D6 (0.44) | CA12CA1CA9CYP2D6CYP1A2 | |
| SCHEMBL20129163 | 0.86 | ALDH1A1 (0.41) | CA12CA1CA9CYP2D6CYP1A2 | |
| SCHEMBL431489 | 0.83 | ACHE (0.39) | CA12CA1CA9CYP2D6CYP1A2 | |
| SCHEMBL15301452 | 0.83 | ACHE (0.39) | CA12CA1CA9CYP2D6CYP1A2 | |
| SCHEMBL15301451 | 0.83 | ACHE (0.39) | CA12CA1CA9CYP2D6CYP1A2 | |
| SCHEMBL431490 | 0.83 | ACHE (0.39) | CA12CA1CA9CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11850216-B2 | 18F labeling of proteins using sortases | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-12-26 | — | — | US | disclosed |
| US-20210038748-A1 | Compositions And Methods For In Vivo Imaging | THE GENERAL HOSPITAL CORPORATION | 2021-02-11 | — | — | US | disclosed |
| US-20200384137-A1 | 18F LABELING OF PROTEINS USING SORTASES | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2020-12-10 | — | — | US | disclosed |
| US-10653805-B2 | Compositions and methods for in vivo imaging | THE GENERAL HOSPITAL CORPORATION (US) | 2020-05-19 | — | — | US | disclosed |
| US-10556024-B2 | 18F labeling of proteins using sortases | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2020-02-11 | — | — | US | disclosed |
| US-20190201562-A1 | Compositions And Methods For In Vivo Imaging | THE GENERAL HOSPITAL CORPORATION | 2019-07-04 | — | — | US | disclosed |
| US-10117954-B2 | Compositions and methods for in vivo imaging | THE GENERAL HOSPITAL CORPORATION (US) | 2018-11-06 | — | — | US | disclosed |
| US-20180015186-A1 | Compositions And Methods For In Vivo Imaging | THE GENERAL HOSPITAL CORPORATION | 2018-01-18 | — | — | US | disclosed |
| US-20180015186-A1 | Compositions And Methods For In Vivo Imaging | THE GENERAL HOSPITAL CORPORATION | 2018-01-18 | — | — | US | disclosed |
| US-9649394-B2 | Compositions and methods for in vivo imaging | THE GENERAL HOSPITAL CORPORATION (US) | 2017-05-16 | — | — | US | disclosed |
| US-9649394-B2 | Compositions and methods for in vivo imaging | THE GENERAL HOSPITAL CORPORATION (US) | 2017-05-16 | — | — | US | disclosed |
| US-20160287734-A1 | 18F LABELING OF PROTEINS USING SORTASES | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2016-10-06 | — | — | US | disclosed |
| US-20160120987-A1 | CHEMICAL STRUCTURES FOR LOCALIZED DELIVERY OF THERAPEUTIC AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-05-05 | — | — | US | disclosed |
| US-20160120987-A1 | CHEMICAL STRUCTURES FOR LOCALIZED DELIVERY OF THERAPEUTIC AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-05-05 | — | — | US | disclosed |
| WO-2015073746-A9 | 18F LABELING OF PROTEINS USING SORTASES | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-07-23 | — | — | WO | disclosed |
| WO-2015073746-A2 | 18F LABELING OF PROTEINS USING SORTASES | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-05-21 | — | — | WO | disclosed |
| US-20130309170-A1 | Compositions And Methods For In Vivo Imaging | THE GENERAL HOSPITAL CORPORATION (US) | 2013-11-21 | — | — | US | disclosed |
| US-20130309170-A1 | Compositions And Methods For In Vivo Imaging | THE GENERAL HOSPITAL CORPORATION (US) | 2013-11-21 | — | — | US | disclosed |
| WO-2012074840-A2 | COMPOSITIONS AND METHODS FOR IN VIVO IMAGING | THE GENERAL HOSPITAL CORPORATION (US) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012074840-A2 | COMPOSITIONS AND METHODS FOR IN VIVO IMAGING | THE GENERAL HOSPITAL CORPORATION (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11850216-B2 | 18F labeling of proteins using sortases | SORT1, ANPEP, SPG11 | CA12 1714/4885CA1 3160/4885CA9 1311/4885 |
| US-20180015186-A1 | Compositions And Methods For In Vivo Imaging | PARP1, PARP11, PARP2 | CA12 3119/4885CA1 2672/4885CA9 3493/4885 |
| US-20160287734-A1 | 18F LABELING OF PROTEINS USING SORTASES | SORT1, ANPEP, SPG11 | CA12 1882/4885CA1 3227/4885CA9 1411/4885 |
| US-20210038748-A1 | Compositions And Methods For In Vivo Imaging | PARP1, PARP11, PARP2 | CA12 3119/4885CA1 2672/4885CA9 3493/4885 |
| US-20130309170-A1 | Compositions And Methods For In Vivo Imaging | PARP1, PARP11, PARP2 | CA12 3119/4885CA1 2672/4885CA9 3493/4885 |
| US-20160120987-A1 | CHEMICAL STRUCTURES FOR LOCALIZED DELIVERY OF THERAPEUTIC AGENTS | FABP1, EPCAM, CD44 | CA12 54/4885CA1 744/4885CA9 395/4885 |
| US-10653805-B2 | Compositions and methods for in vivo imaging | PARP1, PARP11, PARP2 | CA12 3119/4885CA1 2672/4885CA9 3493/4885 |
| US-20200384137-A1 | 18F LABELING OF PROTEINS USING SORTASES | SORT1, ANPEP, SPG11 | CA12 1714/4885CA1 3160/4885CA9 1311/4885 |
| US-10117954-B2 | Compositions and methods for in vivo imaging | PARP1, PARP11, PARP2 | CA12 3119/4885CA1 2672/4885CA9 3493/4885 |
| US-10556024-B2 | 18F labeling of proteins using sortases | SORT1, ANPEP, SPG11 | CA12 1882/4885CA1 3227/4885CA9 1411/4885 |
| US-20190201562-A1 | Compositions And Methods For In Vivo Imaging | PARP1, PARP11, PARP2 | CA12 3119/4885CA1 2672/4885CA9 3493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.