Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.38 |
| ▸ | MAPT | P10636 | 9/20 | 0.38 |
| ▸ | MEN1 | O00255 | 9/20 | 0.38 |
| ▸ | LMNA | P02545 | 7/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | EDNRB | P24530 | 4/20 | 0.34 |
| ▸ | EDNRA | P25101 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4314939 | 1.00 | KMT2A (0.38) | KMT2AMAPTMEN1LMNANPC1 | |
| SCHEMBL4314935 | 0.84 | MAPT (0.38) | KMT2AMAPTMEN1LMNANPC1 | |
| SCHEMBL4314928 | 0.84 | MAPT (0.38) | KMT2AMAPTMEN1LMNANPC1 | |
| SCHEMBL4308256 | 0.83 | MAPT (0.41) | KMT2AMAPTMEN1LMNANPC1 | |
| SCHEMBL4308261 | 0.83 | MAPT (0.41) | KMT2AMAPTMEN1LMNANPC1 | |
| SCHEMBL4321984 | 0.82 | MAPT (0.41) | KMT2AMAPTMEN1LMNANPC1 | |
| SCHEMBL4321978 | 0.82 | MAPT (0.41) | KMT2AMAPTMEN1LMNANPC1 | |
| SCHEMBL4309120 | 0.80 | MAPT (0.45) | KMT2AMAPTMEN1LMNANPC1 | |
| SCHEMBL4309124 | 0.80 | MAPT (0.45) | KMT2AMAPTMEN1LMNANPC1 | |
| SCHEMBL4321039 | 0.79 | ALDH1A1 (0.35) | KMT2AMAPTMEN1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605272-B2 | IGF-1R inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090054508-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1847532-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054508-A1 | IGF-1R INHIBITOR | IGF1R, IGFBP5, IGFBP1 | KMT2A 1924/4885MAPT 4175/4885MEN1 1830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.