Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.73 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.73 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.63 |
| ▸ | BAX | Q07812 | 1/20 | 0.63 |
| ▸ | BACE1 | P56817 | 1/20 | 0.59 |
| ▸ | MMP3 | P08254 | 1/20 | 0.58 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 3/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.56 |
| ▸ | BCR | P11274 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5190092 | 0.94 | ESR2 (0.83) | LTA4HESR2BACE1MMP3BCL2L1 | |
| SCHEMBL26766402 | 0.92 | LTA4H (0.86) | LTA4HESR2NR1H2BAXABL1 | |
| Biphenyl SCHEMBL28073296 | 0.92 | ESR2 (0.78) | LTA4HESR2NR1H2BAXBACE1 | |
| SCHEMBL4307648 | 0.90 | LTA4H (0.77) | LTA4HESR2BACE1ABL1ABCB1 | |
| SCHEMBL20694283 | 0.90 | LTA4H (0.77) | LTA4HESR2BACE1ABL1ABCB1 | |
| SCHEMBL25960632 | 0.90 | LTA4H (0.77) | LTA4HESR2NR1H2BAXMMP3 | |
| SCHEMBL4320112 | 0.90 | LTA4H (0.77) | LTA4HESR2NR1H2BAXMMP3 | |
| SCHEMBL11426529 | 0.88 | LTA4H (0.82) | LTA4HESR2NR1H2BAXMMP3 | |
| SCHEMBL5374943 | 0.86 | LTA4H (0.86) | LTA4HESR2NR1H2BAXMMP3 | |
| SCHEMBL15722134 | 0.86 | LTA4H (0.86) | LTA4HESR2ABL1ABCB1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576102-B2 | Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF (IS) | 2009-08-18 | — | — | US | disclosed |
| US-20070142432-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE CHEMISTRY, INC. (US) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142432-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTA4H, LTC4S, LTB4R | LTA4H 1/4885ESR2 1696/4885NR1H2 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.