Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LPL | P06858 | 2/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 6/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263386 | 0.91 | LPL (0.39) | KMT2AHTTLPLLIPGTNF | |
| SCHEMBL29574549 | 0.91 | LPL (0.39) | KMT2AHTTLPLLIPGTNF | |
| SCHEMBL2026497 | 0.78 | LPL (0.38) | KMT2ALPLLIPGTNFLIPE | |
| SCHEMBL31648336 | 0.78 | JAK2 (0.38) | LPLLIPGTNFLIPE | |
| SCHEMBL25368607 | 0.77 | LPL (0.31) | LPLLIPG | |
| SCHEMBL29819809 | 0.76 | DRD1 (0.42) | KMT2AHTTMEN1TNFHTR1A | |
| SCHEMBL264299 | 0.76 | DRD1 (0.42) | KMT2AHTTMEN1TNFHTR1A | |
| SCHEMBL26197525 | 0.76 | LPL (0.33) | LPLLIPGTNFBACE1 | |
| SCHEMBL13727784 | 0.75 | LPL (0.41) | LPLLIPGTNFCXCR2 | |
| SCHEMBL29878543 | 0.75 | LPL (0.41) | LPLLIPGTNFCXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134179-A1 | FUSED RING HETEROCYCLE KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008124850-A1 | FUSED RING HETEROCYCLE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |