Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4316960 | 1.00 | KDR (0.47) | KDRFGFR1NTRK1NTRK3NTRK2 | |
| SCHEMBL4322650 | 0.81 | KDM4E (0.42) | KDRFGFR1NTRK1NTRK3NTRK2 | |
| SCHEMBL4322654 | 0.81 | KDM4E (0.42) | KDRFGFR1NTRK1NTRK3NTRK2 | |
| SCHEMBL4320481 | 0.80 | PTGS2 (0.52) | KDRFGFR1AURKAAURKB | |
| SCHEMBL4320483 | 0.80 | PTGS2 (0.52) | KDRFGFR1AURKAAURKB | |
| SCHEMBL4319809 | 0.80 | PDPK1 (0.50) | KDRFGFR1NTRK1NTRK3NTRK2 | |
| SCHEMBL4319805 | 0.80 | PDPK1 (0.50) | KDRFGFR1NTRK1NTRK3NTRK2 | |
| SCHEMBL4311295 | 0.78 | PDPK1 (0.40) | KDRFGFR1NTRK1NTRK3NTRK2 | |
| SCHEMBL4311293 | 0.78 | PDPK1 (0.40) | KDRFGFR1NTRK1NTRK3NTRK2 | |
| SCHEMBL4309455 | 0.77 | KDR (0.49) | KDRFGFR1NTRK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605272-B2 | IGF-1R inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090054508-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1847532-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054508-A1 | IGF-1R INHIBITOR | IGF1R, IGFBP5, IGFBP1 | KDR 75/4885FGFR1 18/4885NTRK1 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.