Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | PRKDC | P78527 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508978 | 1.00 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTCYP2D6CYP3A4 | |
| SCHEMBL4321227 | 0.95 | ALDH1A1 (0.59) | ALDH1A1KDM4EMAPTCYP2D6CYP3A4 | |
| SCHEMBL10318577 | 0.95 | ALDH1A1 (0.59) | ALDH1A1KDM4EMAPTCYP2D6CYP3A4 | |
| SCHEMBL27958219 | 0.90 | CYP2D6 (0.66) | ALDH1A1KDM4ECYP2D6CYP1A2CYP2C19 | |
| SCHEMBL6508955 | 0.88 | CYP2D6 (0.53) | ALDH1A1KDM4EMAPTCYP2D6CYP3A4 | |
| SCHEMBL13318973 | 0.88 | CYP2D6 (0.53) | ALDH1A1KDM4EMAPTCYP2D6CYP3A4 | |
| SCHEMBL6508961 | 0.88 | CYP2D6 (0.53) | ALDH1A1KDM4EMAPTCYP2D6CYP3A4 | |
| SCHEMBL361838 | 0.85 | CYP2D6 (0.55) | ALDH1A1KDM4ECYP2D6CYP1A2CYP2C19 | |
| SCHEMBL13388207 | 0.82 | CYP2D6 (0.56) | ALDH1A1KDM4ECYP2D6CYP1A2CYP2C19 | |
| SCHEMBL361837 | 0.82 | KDM4E (0.58) | ALDH1A1KDM4EMAPTCYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605272-B2 | IGF-1R inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090054508-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1847532-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054508-A1 | IGF-1R INHIBITOR | IGF1R, IGFBP5, IGFBP1 | ALDH1A1 1250/4885KDM4E 1251/4885MAPT 4175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.