Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4324022 | 0.87 | KDM4E (0.32) | KDM4EALDH1A1LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL4312051 | 0.87 | KDM4E (0.33) | KDM4E | |
| Hydrochloric Acid SCHEMBL4326066 | 0.86 | KDM4E (0.32) | KDM4EALDH1A1LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL4062027 | 0.82 | ALDH1A1 (0.34) | CYP1A2KDM4EALDH1A1LMNAMAPK1 | |
| SCHEMBL7601191 | 0.80 | MAPT (0.35) | KDM4EALDH1A1LMNAMAPK1MAPT | |
| Hydrochloric Acid SCHEMBL4062488 | 0.79 | HDAC4 (0.34) | CYP1A2 | |
| Hydrochloric Acid SCHEMBL4064038 | 0.79 | — | — | |
| SCHEMBL7599708 | 0.78 | KDM4E (0.31) | CYP1A2KDM4EALDH1A1LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL4312126 | 0.78 | HTR7 (0.31) | — | |
| SCHEMBL796926 | 0.77 | KDM4E (0.31) | KDM4EALDH1A1LMNAMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579416-B2 | Catalyst system for olefin polymerization | BASELL POLYOLEFINE GMBH (DE) | 2009-08-25 | — | — | US | disclosed |
| US-20070149386-A1 | Catalyst system for olefin polymerization | EQUISTAR CHEMICALS, LP | 2007-06-28 | — | — | US | disclosed |
| EP-1697428-A1 | CATALYST SYSTEM FOR OLEFIN POLYMERIZATION | Basell Polyolefine GmbH (DE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005063829-A1 | CATALYST SYSTEM FOR OLEFIN POLYMERIZATION | BASELL POLYOLEFINE GMBH (DE) | 2005-07-14 | — | — | WO | disclosed |