Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 6/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3643699 | 0.85 | CYP4F2 (0.41) | MIFMEN1KMT2ASLC2A1SLC2A4 | |
| SCHEMBL6172318 | 0.82 | CES2 (0.45) | MEN1KMT2AMAPK1CYP1A2 | |
| SCHEMBL27621487 | 0.81 | MEN1 (0.39) | MEN1KMT2ALMNAHTTMAPK1 | |
| SCHEMBL12987528 | 0.81 | CYP4F2 (0.49) | MIFLMNAHTTMAPK1RAB9A | |
| SCHEMBL28615189 | 0.79 | MAP2K1 (0.42) | MEN1KMT2ALMNAHTTMAPK1 | |
| SCHEMBL27984901 | 0.79 | MRGPRX4 (0.44) | MEN1KMT2ALMNAHTTMAPK1 | |
| SCHEMBL5197975 | 0.79 | DGAT1 (0.55) | MEN1KMT2ALMNAHTTRAB9A | |
| SCHEMBL18115522 | 0.79 | PPARG (0.50) | KMT2A | |
| SCHEMBL767991 | 0.78 | SLC2A1 (0.49) | MEN1KMT2ASLC2A1SLC2A4LMNA | |
| SCHEMBL6316992 | 0.78 | CARM1 (0.39) | MIFSLC2A1SLC2A4LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920703-B | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-114920703-A | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-112334460-A | Biaryl ether type quinazoline derivative | 第一三共株式会社 | 2021-02-05 | — | — | CN | disclosed |
| WO-2020009156-A1 | BIARYL ETHER-TYPE QUINAZOLINE DERIVATIVE | 第一三共株式会社 | 2020-01-09 | — | — | WO | disclosed |
| WO-2009136663-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-12 | — | — | WO | disclosed |