Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27689177 | 0.85 | DGAT1 (0.50) | DGAT1KDM4EKMT2AALDH1A1MAPT | |
| SCHEMBL1020566 | 0.81 | CFD (0.51) | DGAT1KDM4EPOLBPKMALDH1A1 | |
| SCHEMBL6172318 | 0.81 | CES2 (0.45) | KDM4EPOLBKMT2AALDH1A1MAPT | |
| SCHEMBL28426175 | 0.79 | ALOX15 (0.43) | DGAT1KDM4EKMT2AALDH1A1MAPT | |
| SCHEMBL4318565 | 0.79 | MIF (0.40) | KMT2AMEN1HTTLMNARAB9A | |
| SCHEMBL27621487 | 0.79 | MEN1 (0.39) | KDM4EPOLBPKMKMT2AALDH1A1 | |
| SCHEMBL18115522 | 0.78 | PPARG (0.50) | KMT2A | |
| SCHEMBL27984901 | 0.78 | MRGPRX4 (0.44) | KMT2AALDH1A1MEN1HTTLMNA | |
| SCHEMBL28615189 | 0.78 | MAP2K1 (0.42) | KMT2AMEN1HTTLMNARAB9A | |
| SCHEMBL6649495 | 0.78 | KMT2A (0.38) | DGAT1KDM4EKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116589467-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligands and methods of use thereof | 百济神州有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-116589466-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligands and methods of use thereof | 百济神州有限公司 | 2023-08-15 | — | — | CN | disclosed |
| EP-4146655-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BeiGene, Ltd. (KY) | 2023-03-15 | — | — | EP | disclosed |
| CN-115485278-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligands and methods of use thereof | 百济神州有限公司 | 2022-12-16 | — | — | CN | disclosed |
| WO-2021219070-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-11-04 | — | — | WO | disclosed |
| CN-113365996-A | Imidazopyridine derivative compounds and uses thereof | 韩美药品株式会社 | 2021-09-07 | — | — | CN | disclosed |
| CN-111902519-A | Liquid crystal composition comprising five-membered heterocyclic ring, reverse mode polymer dispersed liquid crystal element and related selectively dimmable device | 日东电工株式会社 | 2020-11-06 | — | — | CN | disclosed |
| WO-2020159285-A1 | IMIDAZOPYRIDINE DERIVATIVE COMPOUNDS AND USE OF SAME | 한미약품 주식회사 | 2020-08-06 | — | — | WO | disclosed |
| CN-110520413-A | Big ring broad-spectrum antibiotic | RQX PHARMACEUTICALS INC | 2019-11-29 | — | — | CN | disclosed |
| CN-110483501-A | N- (phenyl sulfonyl) benzamide and related compound as BCL-2 inhibitor | UNIV MICHIGAN REGENTS | 2019-11-22 | — | — | CN | disclosed |
| CN-101743234-A | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LAB | 2010-06-16 | — | — | CN | disclosed |
| CN-101511821-A | Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors | ABBOTT LAB (US) | 2009-08-19 | — | — | CN | disclosed |
| CN-101386596-A | 3-alkylidenehydrazino substituted heteroaryl compounds as thrombopoietin receptor activators | NISSAN CHEMICAL IND LTD (JP) | 2009-03-18 | — | — | CN | disclosed |
| CN-100443472-C | 3-alkylidenehydrazino substituted heteroaryl compound and medicine containing the same | NISSAN CHEMICAL IND LTD (JP) | 2008-12-17 | — | — | CN | disclosed |
| CN-101316834-A | 1H-benzimidazole-4-carboxamides substituted with a phenyl group in the 2-position are potent PARP inhibitors | ABBOTT LAB (US) | 2008-12-03 | — | — | CN | disclosed |
| CN-101309908-A | Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors | ABBOTT LAB (US) | 2008-11-19 | — | — | CN | disclosed |
| CN-101305010-A | Raf inhibitor compounds and methods of use thereof | ARRAY BIOPHARMA INC (US) | 2008-11-12 | — | — | CN | disclosed |
| EP-1799677-A1 | OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS | Ranbaxy Laboratories Limited (IN) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038100-A1 | OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS | RANBAXY LABORATORIES LIMITED (IN) | 2006-04-13 | — | — | WO | disclosed |
| CN-1556788-A | Muscarinic agonists | — | 2004-12-22 | — | — | CN | disclosed |