SCHEMBL431858

SCHEMBL431858

O=C/C=C/c1ccc(Cl)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.60
KDM4E B2RXH2 1/20 0.60
MAPT P10636 1/20 0.60
TRPA1 O75762 1/20 0.58
LMNA P02545 1/20 0.58
ALOX5 P09917 1/20 0.58
MAPK1 P28482 1/20 0.58
HSD17B10 Q99714 1/20 0.56
CYP1A2 P05177 1/20 0.52
HDAC2 Q92769 2/20 0.52
HDAC3 O15379 1/20 0.52
HDAC4 P56524 1/20 0.52
HDAC1 Q13547 1/20 0.52
HDAC7 Q8WUI4 1/20 0.52
HDAC10 Q969S8 1/20 0.52
HDAC11 Q96DB2 1/20 0.52
HDAC8 Q9BY41 1/20 0.52
HDAC6 Q9UBN7 1/20 0.52
HDAC9 Q9UKV0 1/20 0.52
HDAC5 Q9UQL6 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL431859 1.00 ALDH1A1 (0.60) ALDH1A1KDM4EMAPTTRPA1LMNA
SCHEMBL27976097 0.98 ALDH1A1 (0.58) ALDH1A1KDM4EMAPTTRPA1LMNA
SCHEMBL8921607 0.93 ALDH1A1 (0.54) ALDH1A1KDM4EMAPTTRPA1LMNA
SCHEMBL2556501 0.91 HDAC3 (0.53) ALDH1A1KDM4EMAPTTRPA1LMNA
SCHEMBL2556498 0.91 HDAC3 (0.53) ALDH1A1KDM4EMAPTTRPA1LMNA
SCHEMBL1310214 0.87 ALDH1A1 (0.75) ALDH1A1KDM4EMAPTTRPA1LMNA
SCHEMBL1310216 0.87 ALDH1A1 (0.75) ALDH1A1KDM4EMAPTTRPA1LMNA
SCHEMBL11451994 0.84 HDAC3 (0.59) LMNAALOX5HSD17B10CYP1A2HDAC2
SCHEMBL2622607 0.84 HDAC3 (0.59) LMNAALOX5HSD17B10CYP1A2HDAC2
SCHEMBL18417175 0.81 HDAC3 (0.57) LMNAALOX5HSD17B10CYP1A2HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 616 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630758-B2 Downhole methods and compositions used in such DORF KETAL CHEMICALS FZE (AE) 2026-05-19 US claimed
US-12497557-B2 Methods for stimulating a hydrocarbon-bearing formation by perforating a wellbore and introducing an acidic composition in the wellbore DORF KETAL CHEMICALS FZE (AE) 2025-12-16 US claimed
US-12241021-B2 Method for fracking of simulation of hydrocarbon bearing formation DORF KETAL CHEMICALS FZE (AE) 2025-03-04 US claimed
CN-119529553-A Smoke-suppressing bird-repelling sand-containing fog sealing layer and preparation method thereof 中国石油化工股份有限公司 2025-02-28 CN claimed
CN-119522906-A Smoke-suppressing bird-repellent microcapsule, smoke-suppressing bird-repellent asphalt additive and preparation method thereof 中国石油化工股份有限公司 2025-02-28 CN claimed
US-12234384-B2 Adhesion-improving composition for textile material and associated reinforcing textile material PORCHER INDUSTRIES (FR) 2025-02-25 US claimed
US-20250011644-A1 NOVEL DOWNHOLE METHODS AND COMPOSITIONS USED IN SUCH DORF KETAL CHEMICALS FZE (AE) 2025-01-09 US claimed
US-20240301277-A1 Methods for Stimulating a Hydrocarbon-bearing Formation by Perforating a Wellbore and Introducing an Acidic Composition in the Wellbore DORF KETAL CHEMICALS FZE (AE) 2024-09-12 US claimed
US-20240279533-A1 DOWNHOLE METHODS AND COMPOSITIONS USED IN SUCH DORF KETAL CHEMICALS FZE (AE) 2024-08-22 US claimed
US-20240254383-A1 NOVEL DOWNHOLE METHODS AND COMPOSITIONS USED IN SUCH DORF KETAL CHEMICALS FZE (AE) 2024-08-01 US claimed
US-6262269-B1 4-Substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries TREGA BIOSCIENCES, INC. 2001-07-17 US claimed
EP-0977989-A1 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES TREGA BIOSCIENCES, INC. (US) 2000-02-09 EP claimed
WO-1998034115-A1 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES TREGA BIOSCIENCES, INC. (US) 1998-08-06 WO claimed
EP-0520336-A2 Aldehyde derivatives and their use as calpain inhibitors FUJIREBIO Inc. (JP) 1992-12-30 EP claimed
US-4925848-A ANALGESICS, SIDE EFFECT REDUCTION RECKITT & COLMAN PRODUCTS LIMITED (GB) 1990-05-15 US claimed
EP-0295783-A2 A derivative of codeine RECKITT AND COLMAN PRODUCTS LIMITED (GB) 1988-12-21 EP claimed
EP-0094283-B1 SUSTAINED-RELEASE THEOPHYLLIN DRUG FORMULATION LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1985-11-21 EP claimed
US-4410696-A Antitumor and immunosuppressive 4-carbamoylimidazolium-5-olate derivatives SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-10-18 US claimed
EP-0075629-A1 Imidazole derivatives, their preparation, and their pharmaceutical compositions Sumitomo Chemical Industries Ltd. (JP) 1983-04-06 EP claimed
US-4369309-A HYPOTENSIVE AGENTS; UASODILATION; CARDIOVASCULAR DISORDERS SS PHARMACEUTICAL CO., LTD. (JP) 1983-01-18 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630758-B2 Downhole methods and compositions used in such IL1B, GET3, IL17A ALDH1A1 4815/4885KDM4E 4625/4885MAPT 4649/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.