SCHEMBL4318737

SCHEMBL4318737

COC(=O)c1ccc(Oc2ncccc2C(F)(F)F)cc1

nearest known ligand 0.59

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.53
▸ P2RY1 P47900 1/20 0.53
▸ TDP1 Q9NUW8 1/20 0.52
▸ MAPT P10636 2/20 0.51
▸ ALDH1A1 P00352 1/20 0.51
▸ ATM Q13315 1/20 0.51
▸ SCN9A Q15858 2/20 0.51
▸ FPR2 P25090 1/20 0.51
▸ KDM4E B2RXH2 1/20 0.48
▸ POLB P06746 1/20 0.48
▸ MEN1 O00255 1/20 0.46
▸ KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2462016 0.86 ALDH1A1 (0.48) MAPTALDH1A1ATMSCN9AFPR2
SCHEMBL4318313 0.85 ALDH1A1 (0.54) MAPTALDH1A1ATMSCN9AFPR2
SCHEMBL12303690 0.81 TDP1 (0.49) P2RY1TDP1MAPTALDH1A1ATM
SCHEMBL11922573 0.81 CFTR (0.51) P2RY1TDP1MAPTALDH1A1ATM
SCHEMBL27514961 0.80 MAPT (0.51) MAPTALDH1A1ATMSCN9AFPR2
SCHEMBL6128279 0.80 TDP1 (0.56) LMNAP2RY1TDP1MAPTALDH1A1
SCHEMBL13331058 0.80 PDE10A (0.56) P2RY1TDP1MAPTALDH1A1KDM4E
SCHEMBL11187255 0.79 ALDH1A1 (0.59) MAPTALDH1A1ATMSCN9AFPR2
SCHEMBL8237109 0.79 ALDH1A1 (0.59) MAPTALDH1A1ATMSCN9AMEN1
SCHEMBL11684169 0.79 ALDH1A1 (0.51) P2RY1MAPTALDH1A1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7566781-B2 Imidazopyridine compound BANYU PHARMACEUTICAL CO., LTD. (JP) 2009-07-28 — — US disclosed
US-20070249659-A1 melanin concentrating hormone receptor antagonist; preventing or treating vascular system diseases, nervous system disorders, metabolic disorders, urogenital diseases, respiratory diseases disorders; N-(2-ethyl-3-methylimidazo[1,2-a]pyridin-6-yl)-3-fluoro-4-(pyridin-2-ylmethoxy)benzamide BANYU PHARMACEUTICAL., LTD. (JP) 2007-10-25 — — US disclosed
EP-1748048-A1 IMIDAZOPYRIDINE COMPOUND BANYU PHARMACEUTICAL CO., LTD. (JP) 2007-01-31 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249659-A1 melanin concentrating hormone receptor antagonist; preventing or treating vascular system diseases, nervous system disorders, metabolic disorders, urogenital diseases, respiratory diseases disorders; N-(2-ethyl-3-methylimidazo[1,2-a]pyridin-6-yl)-3-fluoro-4-(pyridin-2-ylmethoxy)benzamide MC1R, MCHR2, MCHR1 LMNA 3634/4885P2RY1 433/4885TDP1 3482/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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