Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13331058 | 0.83 | PDE10A (0.56) | TDP1MAPTKDM4EPOLBKMT2A | |
| SCHEMBL6120085 | 0.81 | RAB9A (0.67) | TDP1MAPTKDM4EPOLBKMT2A | |
| SCHEMBL4318737 | 0.80 | LMNA (0.53) | TDP1MAPTKDM4EPOLBKMT2A | |
| SCHEMBL14878634 | 0.77 | PDE10A (0.60) | TDP1MAPTKDM4EPOLBKMT2A | |
| SCHEMBL1304356 | 0.77 | MAPT (0.50) | TDP1MAPTKDM4EPOLBL3MBTL1 | |
| SCHEMBL27501722 | 0.76 | CA1 (0.53) | TDP1MAPTKDM4EPOLBKMT2A | |
| SCHEMBL28901154 | 0.75 | CA1 (0.60) | TDP1MAPTKDM4EPOLBKMT2A | |
| SCHEMBL693025 | 0.75 | MAPT (0.62) | TDP1MAPTKDM4EPOLBKMT2A | |
| SCHEMBL3530054 | 0.75 | KMT2A (0.64) | TDP1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL13005228 | 0.74 | PDE10A (0.51) | TDP1MAPTPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |