Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1440262 | 1.00 | MAPT (0.34) | MAPTMGLLKMT2ALMNATSHR | |
| SCHEMBL1439282 | 0.98 | MAPT (0.31) | MAPTLMNATSHR | |
| SCHEMBL1439278 | 0.98 | MAPT (0.31) | MAPTLMNATSHR | |
| SCHEMBL1439027 | 0.89 | — | — | |
| SCHEMBL1439025 | 0.89 | — | — | |
| SCHEMBL3412578 | 0.83 | ALDH1A1 (0.33) | MAPTLMNATSHR | |
| SCHEMBL9998723 | 0.82 | — | — | |
| SCHEMBL1439015 | 0.82 | DAO (0.31) | — | |
| SCHEMBL1439016 | 0.82 | DAO (0.31) | — | |
| SCHEMBL16893866 | 0.79 | LMNA (0.30) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9498483-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2016-11-22 | — | — | US | disclosed |
| US-9498483-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2016-11-22 | — | — | US | disclosed |
| US-9498483-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2016-11-22 | — | — | US | disclosed |
| US-20150224109-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | NOVARTIS AG (CH) | 2015-08-13 | — | — | US | disclosed |
| US-20150224109-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | NOVARTIS AG (CH) | 2015-08-13 | — | — | US | disclosed |
| US-20150224109-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | NOVARTIS AG (CH) | 2015-08-13 | — | — | US | disclosed |
| US-9040690-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2015-05-26 | — | — | US | disclosed |
| US-9040690-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2015-05-26 | — | — | US | disclosed |
| US-9040690-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2015-05-26 | — | — | US | disclosed |
| EP-2595983-A1 | 2,3,5-TRISUBSTITUTED THIOPHENE COMPOUNDS AND USES THEREOF | Novartis AG (CH) | 2013-05-29 | — | — | EP | disclosed |
| US-20130123252-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-05-16 | — | — | US | disclosed |
| US-20130123252-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-05-16 | — | — | US | disclosed |
| US-20130123252-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-05-16 | — | — | US | disclosed |
| WO-2012010663-A9 | 2,3,5-TRISUBSTITUTED THIOPHENE COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2013-01-24 | — | — | WO | disclosed |
| WO-2012010663-A1 | 2,3,5-TRISUBSTITUTED THIOPHENE COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2012-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150224109-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | TPMT, CYP3A5, CYP11B2 | MAPT 2512/4885MGLL 2418/4885KMT2A 4350/4885 |
| US-20130123252-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | TPMT, CYP3A5, CYP11B2 | MAPT 2512/4885MGLL 2418/4885KMT2A 4350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.