Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.70 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4310979 | 0.90 | ALOX5AP (0.58) | ALOX5APPDE10ACYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL4313120 | 0.85 | ALOX5AP (0.84) | ALOX5APCYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL4315018 | 0.83 | ALOX5AP (0.66) | ALOX5APPDE10ACYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL13669030 | 0.79 | ALOX5AP (0.54) | ALOX5APPDE10ACYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL4556998 | 0.78 | ALOX5AP (1.00) | ALOX5APPDE10ACYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL8260654 | 0.78 | PDE10A (0.60) | PDE10ACYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL4318215 | 0.78 | ALOX5AP (0.53) | ALOX5APPDE10ACYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL4307367 | 0.78 | ALOX5AP (0.72) | ALOX5APPDE10ACYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL4320849 | 0.78 | ALOX5AP (0.74) | ALOX5APCYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL4320856 | 0.78 | ALOX5AP (0.74) | ALOX5APPDE10ACYSLTR1CYSLTR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258885-A1 | Diphenylmethane Derivatives as Inhibitors of Leukotriene Biosynthesis | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258885-A1 | Diphenylmethane Derivatives as Inhibitors of Leukotriene Biosynthesis | LTC4S, LTA4H, ALOX5 | ALOX5AP 17/4885PDE10A 1927/4885CYSLTR1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.