Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | BAD | Q92934 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6810992 | 0.75 | DHODH (0.43) | DHODHSLC6A4SLC6A3KMT2A | |
| SCHEMBL7480062 | 0.67 | PTGS2 (0.60) | PTGS2 | |
| SCHEMBL6499224 | 0.67 | SLC6A3 (0.51) | BCL2L1BADSLC6A4SLC6A3KMT2A | |
| SCHEMBL17841452 | 0.63 | KCNH2 (0.40) | HDAC3HDAC1HDAC2PTGS2NPC1 | |
| Bicarbonate SCHEMBL28812694 | 0.62 | BCL2L1 (0.68) | BCL2L1BADAPAF1POLBGRK2 | |
| SCHEMBL202110 | 0.61 | BCL2L1 (1.00) | BCL2L1BADCA12 | |
| SCHEMBL1745534 | 0.61 | CYP17A1 (0.55) | HDAC3HDAC1HDAC2 | |
| SCHEMBL2522507 | 0.60 | NOTUM (0.43) | BCL2L1BADAPAF1POLBGRK2 | |
| SCHEMBL1066181 | 0.59 | MAPK14 (0.43) | BCL2L1BADPTGS2NPC1RAB9A | |
| Bicarbonate SCHEMBL28812688 | 0.59 | BCL2L1 (0.62) | BCL2L1BADPOLBDHODHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270406-A1 | Combination Therapy for the Treatment of Urinary Frequency, Urinary Urgency and Urinary Incontinence | MERCK SHARP & DOHME CORP. | 2009-10-29 | — | — | US | disclosed |
| US-7196113-B2 | Lactam tachykinin receptor antagonists | MERCK & CO., INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-20050282886-A1 | Lactam tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270406-A1 | Combination Therapy for the Treatment of Urinary Frequency, Urinary Urgency and Urinary Incontinence | MME, UTS2R, BPHL | BCL2L1 4481/4885BAD 4075/4885APAF1 4426/4885 |
| US-20050282886-A1 | Lactam tachykinin receptor antagonists | TACR1, TACR2, NPSR1 | BCL2L1 3604/4885BAD 3872/4885APAF1 3325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.