Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | TOP2A | P11388 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 4/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.59 |
| ▸ | CDK2 | P24941 | 4/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.59 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.59 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16758710 | 0.84 | MAP3K5 (0.69) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL1725584 | 0.80 | PAK1 (1.00) | PAK1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL24846509 | 0.79 | CYP1A2 (0.88) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL5144928 | 0.79 | XDH (0.56) | PAK1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL8642694 | 0.78 | PAK1 (0.97) | PAK1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL10927540 | 0.78 | PAK1 (0.97) | PAK1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL9465617 | 0.78 | PAK1 (0.97) | PAK1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL432160 | 0.78 | PAK1 (0.48) | PAK1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL24846512 | 0.77 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL94363 | 0.76 | MAP3K5 (1.00) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318700-B2 | Lung-targeted drugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120122818-A1 | LUNG-TARGETED DRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-05-17 | — | — | US | disclosed |
| US-8101745-B2 | Conjugate cidofovir, idoxuridine, vidarabine, trifluridine, acyclovir, famciclovir penciclovir, valacyclovir, ganciclovir, antiviral, antimicrobial, cancer drug of interest to glycerol ethers or glycerol phosphate ethers | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-01-24 | — | — | US | disclosed |
| US-20080221061-A1 | Lung-Targeted Drugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-09-11 | — | — | US | disclosed |
| WO-2001064693-A1 | PHOSPHONATE NUCLEOTIDE COMPOUND | MITSUBISHI PHARMA CORPORATION (JP) | 2001-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221061-A1 | Lung-Targeted Drugs | DGKG, GK, PHOSPHO1 | PAK1 1138/4885CYP1A2 4057/4885CYP3A4 3814/4885 |
| US-20120122818-A1 | LUNG-TARGETED DRUGS | DGKG, GK, PHOSPHO1 | PAK1 1138/4885CYP1A2 4057/4885CYP3A4 3814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.