SCHEMBL4322973

SCHEMBL4322973

CCOC(=O)Nc1cc(N(C)C)ccc1C(=O)Nc1ccc(C[C@](N)(C(=O)OC)C(=O)c2c(Cl)cccc2Cl)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 1/20 0.42
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
MTNR1A P48039 1/20 0.38
MTNR1B P49286 1/20 0.38
ALDH1A1 P00352 3/20 0.38
TSHR P16473 1/20 0.38
F2R P25116 1/20 0.36
MAPK13 O15264 1/20 0.36
MAPK12 P53778 1/20 0.36
MAPK11 Q15759 1/20 0.36
MAPK14 Q16539 1/20 0.36
DGAT1 O75907 1/20 0.36
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
KDM4E B2RXH2 1/20 0.36
GHSR Q92847 1/20 0.35
ACR P10323 1/20 0.35
KCNQ4 P56696 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1322684 0.79 ITGB1 (0.50) ITGB1ITGA4
SCHEMBL1323600 0.73 ITGB1 (0.50) ITGB1ITGA4
SCHEMBL4315764 0.65 ITGB1 (0.52) ITGB1ITGA4
SCHEMBL7261170 0.62 ITGB1 (0.44) KMT2ATSHRRAB9ASMN1; SMN2MAPT
SCHEMBL7261810 0.62 ITGB1 (0.62) ITGB1ITGA4
SCHEMBL10668361 0.61 MAPK1 (0.62) MEN1KMT2AMTNR1AMTNR1BALDH1A1
SCHEMBL6814567 0.61 RAB9A (0.61) MEN1KMT2AALDH1A1F2RMAPK13
SCHEMBL22017528 0.60 CYP1A2 (0.54) MEN1KMT2AMTNR1AMTNR1BALDH1A1
SCHEMBL13602372 0.60 ALDH1A1 (0.71) MEN1KMT2AALDH1A1TSHRMAPK13
SCHEMBL6999775 0.60 ALDH1A1 (0.71) ALDH1A1SMN1; SMN2KDM4EMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2103601-A1 PROCESS FOR PRODUCTION OF PHENYLALANINE DERIVATIVES HAVING QUINAZOLINEDIONE SKELETONS AND INTERMEDIATES FOR THE PRODUCTION Ajinomoto Co., Inc. (JP) 2009-09-23 EP disclosed