Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | FABP3 | P05413 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13602372 | 0.88 | ALDH1A1 (0.71) | ALDH1A1HPGDNLRP3GPR35CYP1A2 | |
| SCHEMBL10489654 | 0.85 | ALDH1A1 (0.57) | ALDH1A1HPGDNLRP3TRPM4CYP1A2 | |
| SCHEMBL8657531 | 0.84 | ALDH1A1 (0.56) | ALDH1A1HPGDNLRP3PLK1CYP1A2 | |
| SCHEMBL10489851 | 0.84 | ALDH1A1 (0.56) | ALDH1A1HPGDNLRP3CYP1A2CYP2C9 | |
| SCHEMBL3803167 | 0.83 | ALDH1A1 (0.77) | ALDH1A1HPGDNLRP3GPR35CYP1A2 | |
| SCHEMBL1189632 | 0.83 | ALDH1A1 (0.77) | ALDH1A1HPGDNLRP3CYP1A2CYP2C9 | |
| SCHEMBL27474459 | 0.82 | ALDH1A1 (0.62) | ALDH1A1HPGDNLRP3CYP1A2CYP2C9 | |
| SCHEMBL3788964 | 0.82 | ALDH1A1 (0.75) | ALDH1A1HPGDNLRP3GPR35CYP1A2 | |
| SCHEMBL3784358 | 0.81 | ALDH1A1 (0.73) | ALDH1A1HPGDNLRP3GPR35CYP1A2 | |
| SCHEMBL10489823 | 0.80 | NLRP3 (0.60) | ALDH1A1HPGDNLRP3CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980374-B1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PFIZER HOLDING FRANCE (FR) | 2003-02-12 | — | — | EP | disclosed |
| US-6239130-B1 | ASTHMA, ATOPIC DERMATITIS, RHEUMATOID ARTHRITIS, INFLAMMATORY BOWEL DISORDERS, PULMONARY HYPERTENSION, LIVER INJURY, BONE LOSS, SEPTIC SHOCK, OR MULTIPLE SCLEROSIS, | WARNER-LAMBERT COMPANY | 2001-05-29 | — | — | US | disclosed |
| EP-0980374-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998049169-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 1998-11-05 | — | — | WO | disclosed |