Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.82 |
| ▸ | LTA4H | P09960 | 5/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13703549 | 1.00 | HRH1 (0.82) | HRH1LTA4HSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4324950 | 1.00 | HRH1 (0.82) | HRH1LTA4HSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL4328367 | 0.98 | HRH1 (0.80) | HRH1LTA4HSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL4328357 | 0.98 | HRH1 (0.80) | HRH1LTA4HSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14578145 | 0.94 | HRH1 (0.71) | HRH1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL24437475 | 0.90 | HRH1 (1.00) | HRH1LTA4HSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19724789 | 0.87 | HRH1 (0.62) | HRH1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL23475145 | 0.85 | HRH1 (0.60) | HRH1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL14828522 | 0.85 | HRH1 (0.78) | HRH1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL2523551 | 0.85 | HRH1 (0.78) | HRH1SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233969-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-09-17 | — | — | US | disclosed |
| US-20090233969-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-09-17 | — | — | US | disclosed |
| US-20090233969-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-09-17 | — | — | US | disclosed |
| US-7576102-B2 | Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF (IS) | 2009-08-18 | — | — | US | disclosed |
| US-7576102-B2 | Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF (IS) | 2009-08-18 | — | — | US | disclosed |
| US-7576102-B2 | Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF (IS) | 2009-08-18 | — | — | US | disclosed |
| EP-1963261-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | Decode Genetics EHF (IS) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007073407-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2007-06-28 | — | — | WO | disclosed |
| WO-2007073407-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2007-06-28 | — | — | WO | disclosed |
| US-20070142432-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE CHEMISTRY, INC. (US) | 2007-06-21 | — | — | US | disclosed |
| US-20070142432-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE CHEMISTRY, INC. (US) | 2007-06-21 | — | — | US | disclosed |
| US-20070142432-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE CHEMISTRY, INC. (US) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233969-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTA4H, LTC4S, LTB4R | HRH1 51/4885LTA4H 1/4885SLC6A2 4163/4885 |
| US-20070142432-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTA4H, LTC4S, LTB4R | HRH1 51/4885LTA4H 1/4885SLC6A2 4163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.