SCHEMBL432650

SCHEMBL432650

CC[C](C)c1ccc(Cl)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.44
CES1 P23141 2/20 0.44
GSK3B P49841 2/20 0.43
MAOA P21397 1/20 0.43
MAOB P27338 1/20 0.43
PTGS1 P23219 1/20 0.43
HTT P42858 2/20 0.42
TSHR P16473 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
ALOX15 P16050 1/20 0.42
CYP3A4 P08684 1/20 0.42
MAPK1 P28482 1/20 0.42
ATM Q13315 1/20 0.42
LMNA P02545 4/20 0.42
POLB P06746 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
ALDH1A1 P00352 3/20 0.41
MAPT P10636 3/20 0.41
KDM4E B2RXH2 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11712750 0.93 CYP1A2 (0.41) CES2CES1GSK3BMAOAMAOB
SCHEMBL6326250 0.87 ESR1 (0.43) CES2CES1PTGS1TSHRL3MBTL1
SCHEMBL11775179 0.81 POLB (0.42) CES2CES1GSK3BMAOAMAOB
SCHEMBL11722472 0.78 ALDH1A1 (0.47) CES2CES1HTTL3MBTL1LMNA
SCHEMBL7768582 0.77 ESR1 (0.61) PTGS1TSHRALOX15CYP3A4MAPK1
SCHEMBL28569193 0.76 GSK3B (0.45) CES2CES1GSK3BPTGS1HTT
SCHEMBL28569198 0.76 GSK3B (0.45) CES2CES1GSK3BPTGS1HTT
SCHEMBL8017500 0.75 HTR7 (0.45) CES2CES1MAOBLMNAALDH1A1
SCHEMBL16960595 0.74 TSHR (0.47) MAOAMAOBHTTTSHRMEN1
SCHEMBL453359 0.74 ATM (0.52) CES2CES1HTTTSHRL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595985-A1 ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES Syngenta Participations AG (CH) 2013-05-29 EP disclosed
EP-2595984-A1 MICROBICIDES Syngenta Participations AG (CH) 2013-05-29 EP disclosed
WO-2012010568-A1 MICROBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2012-01-26 WO disclosed
WO-2012010567-A1 ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2012-01-26 WO disclosed
US-6103732-A ENDOTHELIN RECEPTOR INHIBITORS; HYPOTENSIVE AGENTS, CARDIOTONIC AGENTS; ACUTE MYOCARDIAL INFARCT, PULMONARY HYPERTENSION, RAYNAUD'S SYNDROME, ATHEROSCLEROSIS; ASTHMA; CARDIOVASCULAR DISORDERS BASF AKTIENGESELLSCHAFT (DE) 2000-08-15 US disclosed
EP-0635485-B1 TETRAHYDROPHTHALAMIDE DERIVATIVE, INTERMEDIATE FOR PRODUCING THE SAME, PRODUCTION OF BOTH, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT SAGAMI CHEM RES (JP) 1997-06-11 EP disclosed
US-5554581-A Tetrahydrophthalamide derivative, intermediate for producing the same, production of both, and herbicide containing the same as active ingredient SAGAMI CHEMICAL RESEARCH CENTER (JP) 1996-09-10 US disclosed
US-5506190-A Tetrahydrophthalamide derivative, intermediate for producing the same, production of both, and herbicide containing the same as active ingredient SAGAMI CHEMICAL RESEARCH CENTER (JP) 1996-04-09 US disclosed
EP-0635485-A1 TETRAHYDROPHTHALAMIDE DERIVATIVE, INTERMEDIATE FOR PRODUCING THE SAME, PRODUCTION OF BOTH, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT SAGAMI CHEMICAL RESEARCH CENTER (JP) 1995-01-25 EP disclosed
US-4053478-A ARTERIOSCLEROSIS, THROMBOSIS, HYPERTENSION YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JA) 1977-10-11 US disclosed
US-4012412-A USEFUL IN THE TREATMENT OF HYPERTENSION, ARTERIOSCLEROSIS, AND THROMBOSIS YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JA) 1977-03-15 US disclosed
US-3931218-A HYPOGLYCEMIC ANTIRESERPINE, ANTIULCER, OGENIC, ANTIARRHYTHMIA AMERICAN HOME PRODUCTS CORPORATION (US) 1976-01-06 US disclosed