Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 12/20 | 0.55 |
| ▸ | ATP4B | P51164 | 12/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.49 |
| ▸ | ACR | P10323 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4330172 | 0.86 | MAPT (0.55) | MAPTNPC1RAB9ASMN1; SMN2SREBF2 | |
| SCHEMBL4331865 | 0.83 | ATP4A (0.76) | ATP4AATP4BMAPTNPC1RAB9A | |
| SCHEMBL4329794 | 0.82 | ATP4A (0.66) | ATP4AATP4BMAPTNPC1RAB9A | |
| SCHEMBL4330723 | 0.82 | PRSS1 (0.61) | ATP4AATP4BMAPTNPC1RAB9A | |
| SCHEMBL4322564 | 0.82 | ATP4A (0.54) | ATP4AATP4BMAPTNPC1RAB9A | |
| SCHEMBL4326708 | 0.81 | MAPT (0.53) | MAPTNPC1RAB9ASMN1; SMN2SREBF2 | |
| SCHEMBL4324204 | 0.79 | ATP4A (0.55) | ATP4AATP4BMAPTNPC1RAB9A | |
| SCHEMBL11547222 | 0.77 | RARB (0.64) | MAPTNPC1SMN1; SMN2PRSS1ACR | |
| SCHEMBL11553184 | 0.77 | RARB (0.64) | MAPTNPC1SMN1; SMN2PRSS1ACR | |
| Bromide SCHEMBL826037 | 0.76 | NPC1 (0.69) | ATP4AATP4BMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146013-A1 | MYOSIN LIGHT CHAIN PHOSPHATASE INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2009-12-03 | — | — | WO | claimed |
| WO-2009146013-A1 | MYOSIN LIGHT CHAIN PHOSPHATASE INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2009-12-03 | — | — | WO | disclosed |