Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 8/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28189368 | 0.80 | HCAR2 (0.38) | HCAR2KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL28003019 | 0.77 | ALOX15 (0.38) | HCAR2KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL965251 | 0.75 | NOTUM (0.51) | HCAR2KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL3507485 | 0.74 | POLB (0.48) | HCAR2KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL27810412 | 0.73 | HCAR2 (0.44) | HCAR2KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL481904 | 0.73 | KDM4E (0.58) | KDM4EKMT2AALDH1A1MEN1GRM1 | |
| SCHEMBL4763042 | 0.72 | HTT (0.45) | HCAR2KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL22289328 | 0.72 | HCAR2 (0.40) | HCAR2KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL27969677 | 0.71 | CA12 (0.32) | KMT2AALDH1A1 | |
| SCHEMBL3511819 | 0.70 | KDM4E (0.53) | HCAR2KDM4EKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549875-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | Merck Sharp & Dohme Corp. (US) | 2013-01-30 | — | — | EP | claimed |
| WO-2011119518-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2011-09-29 | — | — | WO | claimed |
| CN-103396399-B | Nitrogenated aromatic 6-membered ring derivative, and pharmaceutical agent comprising same | DAIICHI SANKYO CO LTD | 2015-04-29 | — | — | CN | disclosed |
| WO-2012010578-A1 | SUBSTITUTED METHYL-PYRIMIDIN-5-YL CARBAMATES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012010578-A1 | SUBSTITUTED METHYL-PYRIMIDIN-5-YL CARBAMATES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-26 | — | — | WO | disclosed |