SCHEMBL43313

SCHEMBL43313

COC(C)(C)c1ccc(C(C)(C)OC)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.46
ALDH1A1 P00352 4/20 0.42
ALOX15 P16050 2/20 0.42
HSD11B1 P28845 1/20 0.37
RORC P51449 1/20 0.37
TSHR P16473 2/20 0.36
HSD17B10 Q99714 3/20 0.35
HPGD P15428 3/20 0.35
LMNA P02545 1/20 0.35
TYR P14679 1/20 0.35
ESR1 P03372 1/20 0.35
CYP3A4 P08684 1/20 0.35
AR P10275 1/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
HTR6 P50406 1/20 0.35
ESRRG P62508 1/20 0.35
SLC6A3 Q01959 1/20 0.35
ESR2 Q92731 1/20 0.35
MAPT P10636 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18253223 0.91 TSHR (0.50) MAPK1ALDH1A1ALOX15TSHRHSD17B10
SCHEMBL4188808 0.91 KIF11 (0.41) MAPK1ALDH1A1ALOX15HSD11B1RORC
SCHEMBL9508337 0.89 TSHR (0.55) MAPK1ALDH1A1ALOX15HSD11B1RORC
SCHEMBL779949 0.87 ALDH1A1 (0.50) MAPK1ALDH1A1ALOX15TSHRHSD17B10
SCHEMBL18905275 0.87 MAPK1 (0.37) MAPK1ALDH1A1ALOX15HSD11B1RORC
SCHEMBL8672704 0.87 CA1 (0.55) MAPK1ALDH1A1ALOX15HSD11B1TSHR
SCHEMBL1738300 0.87 CYP2A6 (0.40) MAPK1ALDH1A1ALOX15HSD11B1RORC
SCHEMBL9359821 0.87 MAPK1 (0.37) MAPK1ALDH1A1ALOX15HSD11B1RORC
SCHEMBL11700789 0.87 ESR1 (0.56) ALDH1A1ALOX15TSHRHSD17B10HPGD
SCHEMBL42639 0.85 MAPK1 (0.67) MAPK1ALDH1A1ALOX15TSHRESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 473 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109694454-A Preparation method of block copolymer and monovinylarene-isomonoolefin-monovinylarene block copolymer 中国石油化工股份有限公司 2019-04-30 CN claimed
CN-109694453-A Preparation method of block copolymer and monovinylarene-isomonoolefin-monovinylarene block copolymer 中国石油化工股份有限公司 2019-04-30 CN claimed
EP-2284203-B1 Method for preparation of polyolefins containing exo-olefin chain ends CHEVRON ORONITE CO (US) 2015-03-04 EP claimed
EP-1572752-B1 POLYMERIZATION PROCESSES EXXONMOBIL CHEM PATENTS INC (US) 2014-08-13 EP claimed
US-8575279-B2 Method for preparation of polyolefins containing exo-olefin chain ends CHEVRON ORONITE COMPANY LLC (US) 2013-11-05 US claimed
US-20130150539-A1 METHOD FOR PREPARATION OF POLYOLEFINS CONTAINING EXO-OLEFIN CHAIN ENDS THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) 2013-06-13 US claimed
EP-1578806-B1 POLYMERIZATION PROCESSES EXXONMOBIL CHEM PATENTS INC (US) 2013-05-22 EP claimed
US-8383736-B2 Method for preparation of polyolefins containing exo-olefin chain ends CHEVRON ORONITE COMPANY LLC (US) 2013-02-26 US claimed
EP-1572753-B1 POLYMERIZATION PROCESSES EXXONMOBIL CHEM PATENTS INC (US) 2012-06-13 EP claimed
US-8063154-B2 Preparation of exo-olefin terminated polyolefins via quenching with alkoxysilanes or ethers THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) 2011-11-22 US claimed
EP-0609737-B1 Process for producing a halogenated butyl rubber BAYER INC (CA) 2000-06-07 EP claimed
US-5473029-A Copolymerization of isobutylene with a conjugated diolefin bearing an allylic halide in the presence of an initiator and a lewis acid BAYER RUBBER INC. (CA) 1995-12-05 US claimed
US-5399646-A Alkylidenenorbornene polymer and process for producing the same NIPPON ZEON CO., LTD. (JP) 1995-03-21 US claimed
EP-0609737-A2 Process for producing a halogenated butyl rubber BAYER RUBBER INC. (CA) 1994-08-10 EP claimed
US-RE34640-E Polymerizing isobutylene, adding monomer to make block polymer; metal halide, initiator and electron pair doner solvent UNIVERSITY OF AKRON (US) 1994-06-14 US claimed
EP-0341012-B1 UNIFORM MOLECULAR WEIGHT POLYMERS EDISON POLYMER INNOVATION CORPORATION ( EPIC) (US) 1992-12-30 EP claimed
WO-1991011468-A1 NEW THERMOPLASTIC ELASTOMERS THE UNIVERSITY OF AKRON (US) 1991-08-08 WO claimed
US-4946899-A CARBOCATIONIC POLYMERIZATION INVOLVING HOMOPOLYMERIZATION OF ELASTOMER FOLLOWED BY COPOLYMERIZATION TO ADD GLASSY SEGMENTS; FORMING LIVING POLYMERS WITH A METAL HALIDE, PROMOTER AND SOLVENT MIXTURE THE UNIVERSITY OF AKRON (US) 1990-08-07 US claimed
EP-0346919-A2 Improved thermoplastic elastomers EDISON POLYMER INNOVATION CORPORATION ( EPIC) (US) 1989-12-20 EP claimed
EP-0341012-A2 Uniform molecular weight polymers EDISON POLYMER INNOVATION CORPORATION ( EPIC) (US) 1989-11-08 EP claimed