Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 5/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3638890 | 0.85 | GHSR (0.48) | GHSRNR1H4TSHRSCN9ASCN5A | |
| SCHEMBL12168922 | 0.84 | GHSR (0.49) | GHSRNR1H4TSHRSCN9ASCN5A | |
| SCHEMBL3638644 | 0.81 | GHSR (0.50) | GHSRNR1H4TSHRSCN9ASCN5A | |
| SCHEMBL3637567 | 0.81 | GHSR (0.51) | GHSRNR1H4TSHRSCN9ASCN5A | |
| SCHEMBL4335252 | 0.81 | GHSR (0.50) | GHSRNR1H4TSHRSCN9ASCN5A | |
| SCHEMBL3642232 | 0.80 | GHSR (0.49) | GHSRNR1H4TSHRSCN9ASCN5A | |
| SCHEMBL2006425 | 0.80 | NR1H4 (0.59) | NR1H4 | |
| SCHEMBL12168916 | 0.77 | SCN9A (0.43) | GHSRNR1H4TSHRSCN9ASCN5A | |
| SCHEMBL4339365 | 0.77 | GHSR (0.42) | GHSRNR1H4SCN9ASCN5ATDP1 | |
| SCHEMBL6081424 | 0.74 | ALDH1A1 (0.49) | GHSRTSHRTDP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079307-A2 | FARNESOID X RECEPTOR AGONISTS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008051942-A2 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |