SCHEMBL4333343

SCHEMBL4333343

CC(C)OC(Cc1ccc(F)c(COC(=O)Nc2ccc(C(F)(F)F)cc2)c1)C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 15/20 0.44
PPARG P37231 10/20 0.44
PPARD Q03181 7/20 0.44
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MGLL Q99685 1/20 0.42
FPR2 P25090 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4341998 0.89 CYP1A2 (0.43) PPARAPPARGPPARDMEN1KMT2A
SCHEMBL4348494 0.89 MGLL (0.40) PPARAPPARGPPARDMEN1KMT2A
SCHEMBL4328750 0.89 PPARA (0.56) PPARAPPARGPPARD
SCHEMBL4335678 0.89 PPARA (0.44) PPARAPPARGPPARDMEN1KMT2A
SCHEMBL4329694 0.89 MGLL (0.48) PPARAPPARGPPARDMEN1KMT2A
SCHEMBL4339384 0.88 NPC1 (0.43) PPARAPPARGPPARDKMT2ASMN1; SMN2
SCHEMBL13810557 0.87 PPARA (0.50) PPARAPPARGPPARD
SCHEMBL4347142 0.87 MEN1 (0.52) PPARAPPARGPPARDMEN1KMT2A
SCHEMBL4334181 0.87 MEN1 (0.52) PPARAPPARGPPARDMEN1KMT2A
SCHEMBL6651780 0.87 PPARA (0.57) PPARAPPARGPPARDFPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7544835-B2 Carboxylic acid derivative and salt thereof EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-06-09 US disclosed
US-7544835-B2 Carboxylic acid derivative and salt thereof EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-06-09 US disclosed
US-7544835-B2 Carboxylic acid derivative and salt thereof EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-06-09 US disclosed