Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4341998 | 0.90 | CYP1A2 (0.43) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4348494 | 0.90 | MGLL (0.40) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4343670 | 0.89 | TSHR (0.44) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4333343 | 0.88 | PPARA (0.44) | SMN1; SMN2FPR2KMT2APPARGPPARD | |
| SCHEMBL6652955 | 0.86 | KDM4E (0.49) | NPC1RAB9ASMN1; SMN2FPR2MAPT | |
| SCHEMBL13810555 | 0.86 | PPARG (0.41) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4335156 | 0.86 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4328737 | 0.84 | FPR2 (0.48) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4341155 | 0.84 | ALDH1A1 (0.48) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL4337170 | 0.83 | MMP1 (0.44) | SMN1; SMN2CYP1A2CYP2D6CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544835-B2 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| US-7544835-B2 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| US-7544835-B2 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |