Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28575301 | 0.81 | ATM (0.41) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL29676432 | 0.81 | ATM (0.41) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL22123120 | 0.80 | ALDH1A1 (0.48) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL14904774 | 0.76 | CRHBP (0.48) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL12604704 | 0.75 | PDGFRB (0.56) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL4333646 | 0.74 | HTT (0.47) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL3034317 | 0.71 | MAPT (0.53) | KMT2AALDH1A1MEN1GAAMAPK1 | |
| SCHEMBL28583372 | 0.71 | MAPT (0.45) | KMT2AALDH1A1GAAMAPK1LMNA | |
| SCHEMBL19354405 | 0.71 | PDGFRB (0.76) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL13468195 | 0.71 | KMT2A (0.58) | KMT2AALDH1A1MEN1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009145357-A1 | IN 1-POSITION DURCH EINEN RING SUBSTITUIERTE BENZO [1, 4] DIAZEPINE ZUR VERWENDUNGS ALS ANTIDEPRESSIVA | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-12-03 | — | — | WO | disclosed |