Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12604704 | 0.76 | PDGFRB (0.56) | HTTPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL4333642 | 0.74 | PDGFRB (0.49) | HTTPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL19354405 | 0.72 | PDGFRB (0.76) | HTTPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8137115 | 0.70 | TSHR (0.53) | HTTALDH1A1TDP1POLBMAPT | |
| SCHEMBL13483711 | 0.70 | TSHR (0.44) | HTTRECQLALDH1A1TDP1MAPT | |
| SCHEMBL27474529 | 0.70 | ALDH1A1 (0.57) | HTTPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8842436 | 0.70 | RECQL (0.45) | HTTPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL9860199 | 0.69 | ALDH1A1 (0.44) | HTTRECQLALDH1A1POLBMAPT | |
| SCHEMBL8142965 | 0.69 | TSHR (0.43) | HTTRECQLALDH1A1TDP1MAPT | |
| SCHEMBL8810085 | 0.69 | MAPT (0.54) | HTTRECQLALDH1A1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009145357-A1 | IN 1-POSITION DURCH EINEN RING SUBSTITUIERTE BENZO [1, 4] DIAZEPINE ZUR VERWENDUNGS ALS ANTIDEPRESSIVA | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-12-03 | — | — | WO | disclosed |