Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31245798 | 1.00 | CYP11B1 (0.47) | CYP11B1CYP11B2TSHRPTGS1KIF11 | |
| Ethyne SCHEMBL28213903 | 0.96 | CYP11B1 (0.45) | CYP11B1CYP11B2TSHRPTGS1KIF11 | |
| SCHEMBL16945906 | 0.85 | PTPRC (0.44) | CYP11B1CYP11B2PTGS1KIF11GABRG2 | |
| SCHEMBL31463164 | 0.84 | TSHR (0.57) | CYP11B2TSHRPTGS1KIF11GABRG2 | |
| SCHEMBL7060500 | 0.84 | BCAT1 (0.45) | CYP11B1CYP11B2TSHRPTGS1KIF11 | |
| SCHEMBL12856701 | 0.82 | PTPRC (0.56) | ALDH1A1MAPTL3MBTL1PDK2PTPRC | |
| SCHEMBL10304838 | 0.81 | CYP11B2 (0.42) | CYP11B1CYP11B2PTGS1KIF11GABRG2 | |
| SCHEMBL3422469 | 0.80 | TSHR (0.59) | CYP11B2TSHRKIF11GABRG2GABRB3 | |
| SCHEMBL19308493 | 0.80 | KIF11 (0.54) | CYP11B1CYP11B2TSHRPTGS1KIF11 | |
| SCHEMBL18499494 | 0.80 | KIF11 (0.54) | CYP11B1CYP11B2TSHRPTGS1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1633287-A | Biphenil derivatives and their use as antiandrogenic agents | ENDORECH INC (CA) | 2005-06-29 | — | — | CN | claimed |
| US-5714087-A | CONTAINING LIQUID CRYSTAL MIXTURE OF SPECIFIED COMPONENTS INCLUDING OPTICALLY ACTIVE COMPONENT | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-02-03 | — | — | US | claimed |
| EP-0713515-B1 | SUPERTWIST LIQUID-CRYSTAL DISPLAY | MERCK PATENT GMBH (DE) | 1997-11-26 | — | — | EP | claimed |
| EP-0713515-A1 | SUPERTWIST LIQUID-CRYSTAL DISPLAY | MERCK PATENT GmbH (DE) | 1996-05-29 | — | — | EP | claimed |
| WO-1995004789-A1 | SUPERTWIST LIQUID-CRYSTAL DISPLAY | MERCK PATENT GMBH (DE) | 1995-02-16 | — | — | WO | claimed |
| US-11179710-B2 | Direct palladium-catalyzed aromatic fluorination | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-11-23 | — | — | US | disclosed |
| US-11179710-B2 | Direct palladium-catalyzed aromatic fluorination | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-11-23 | — | — | US | disclosed |
| EP-3426654-B1 | DIRECT PALLADIUM-CATALYZED AROMATIC FLUORINATION | HARVARD COLLEGE (US) | 2021-10-20 | — | — | EP | disclosed |
| EP-3426654-B1 | DIRECT PALLADIUM-CATALYZED AROMATIC FLUORINATION | HARVARD COLLEGE (US) | 2021-10-20 | — | — | EP | disclosed |
| US-20190099748-A1 | DIRECT PALLADIUM-CATALYZED AROMATIC FLUORINATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-04-04 | — | — | US | disclosed |
| US-20190099748-A1 | DIRECT PALLADIUM-CATALYZED AROMATIC FLUORINATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-04-04 | — | — | US | disclosed |
| EP-3426654-A1 | DIRECT PALLADIUM-CATALYZED AROMATIC FLUORINATION | President and Fellows of Harvard College (US) | 2019-01-16 | — | — | EP | disclosed |
| WO-2014094949-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2014-06-26 | — | — | WO | disclosed |
| WO-2013004333-A1 | BIMESOGENIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2013-01-10 | — | — | WO | disclosed |
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
| CN-1633287-A | Biphenil derivatives and their use as antiandrogenic agents | ENDORECH INC (CA) | 2005-06-29 | — | — | CN | disclosed |
| US-5714087-A | CONTAINING LIQUID CRYSTAL MIXTURE OF SPECIFIED COMPONENTS INCLUDING OPTICALLY ACTIVE COMPONENT | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-02-03 | — | — | US | disclosed |
| EP-0713515-B1 | SUPERTWIST LIQUID-CRYSTAL DISPLAY | MERCK PATENT GMBH (DE) | 1997-11-26 | — | — | EP | disclosed |
| EP-0713515-A1 | SUPERTWIST LIQUID-CRYSTAL DISPLAY | MERCK PATENT GmbH (DE) | 1996-05-29 | — | — | EP | disclosed |
| WO-1995004789-A1 | SUPERTWIST LIQUID-CRYSTAL DISPLAY | MERCK PATENT GMBH (DE) | 1995-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | GRM1, GRIN1, GRM3 | CYP11B1 268/4885CYP11B2 321/4885TSHR 408/4885 |
| US-11179710-B2 | Direct palladium-catalyzed aromatic fluorination | KRAS, NRAS, DDT | CYP11B1 1715/4885CYP11B2 1550/4885TSHR 203/4885 |
| US-20190099748-A1 | DIRECT PALLADIUM-CATALYZED AROMATIC FLUORINATION | KRAS, NRAS, DDT | CYP11B1 1715/4885CYP11B2 1550/4885TSHR 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.