Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 11/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4326551 | 0.83 | PDE4D (0.47) | SMN1; SMN2TRIM24NR3C1CYP17A1BRPF1 | |
| SCHEMBL4465297 | 0.83 | HTR2C (0.40) | SMN1; SMN2ALDH1A1HTR2C | |
| SCHEMBL4326546 | 0.76 | PDE4D (0.59) | SMN1; SMN2TRIM24NR3C1CYP17A1HTR2C | |
| SCHEMBL4032068 | 0.74 | PDE4D (0.57) | — | |
| SCHEMBL4051723 | 0.69 | PDE4A (0.38) | TRIM24NR3C1CYP17A1BRPF1ALDH1A1 | |
| SCHEMBL4053327 | 0.69 | CYP17A1 (0.37) | NR3C1CYP17A1 | |
| SCHEMBL4059118 | 0.68 | CYP17A1 (0.35) | CYP17A1 | |
| SCHEMBL4326731 | 0.65 | HTR2C (0.40) | SMN1; SMN2ALDH1A1HTR2C | |
| SCHEMBL7013290 | 0.62 | PDE4A (0.53) | SMN1; SMN2NR3C1ALDH1A1 | |
| SCHEMBL7020949 | 0.61 | PDE4A (0.53) | SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | claimed |
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | disclosed |