Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 7/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4326551 | 0.91 | PDE4D (0.47) | PDE4DPDE4BCYP17A1SMN1; SMN2TRIM24 | |
| SCHEMBL4326737 | 0.83 | PDE4B (0.44) | PDE4DPDE4BPDE4APDE4CSMN1; SMN2 | |
| SCHEMBL3306175 | 0.78 | PDE4D (0.69) | PDE4DPDE4BPDE4APDE4CSMN1; SMN2 | |
| SCHEMBL4335222 | 0.76 | SMN1; SMN2 (0.39) | CYP17A1SMN1; SMN2TRIM24NR3C1HTR2C | |
| Oglemilast SCHEMBL29413215 | 0.74 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4C | |
| Oglemilast SCHEMBL220245 | 0.74 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4C | |
| Oglemilast SCHEMBL29369504 | 0.74 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4C | |
| Oglemilast SCHEMBL4030005 | 0.74 | PDE4D (0.98) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL4326731 | 0.74 | HTR2C (0.40) | SMN1; SMN2HTR2C | |
| Oglemilast SCHEMBL4030019 | 0.74 | PDE4D (0.98) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | claimed |
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | disclosed |