Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR1B | P28222 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4335222 | 0.83 | SMN1; SMN2 (0.39) | HTR2CALDH1A1SMN1; SMN2 | |
| SCHEMBL4326731 | 0.82 | HTR2C (0.40) | HTR2CLMNAMAPTHTTNPC1 | |
| SCHEMBL4030576 | 0.77 | ALDH1A1 (0.47) | LMNAMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4026837 | 0.76 | MAPT (0.45) | LMNAMAPTHTTALDH1A1KMT2A | |
| SCHEMBL4326737 | 0.74 | PDE4B (0.44) | HTR2CLMNAMAPTHTTNPC1 | |
| SCHEMBL4028106 | 0.72 | PDE4D (0.52) | — | |
| SCHEMBL4055213 | 0.69 | MAPT (0.48) | LMNAMAPTHTTALDH1A1KMT2A | |
| SCHEMBL4050626 | 0.67 | PDE4A (0.39) | LMNAMAPTHTTSIGMAR1ALDH1A1 | |
| SCHEMBL4050217 | 0.67 | BACE1 (0.32) | LMNAMAPTSIGMAR1ALDH1A1HTR1A | |
| SCHEMBL5016430 | 0.66 | GAA (0.43) | MAPTHTTNPC1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | disclosed |