Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4326737 | 0.90 | PDE4B (0.44) | HTR2CMAPTHTTLMNANPC1 | |
| SCHEMBL4326551 | 0.83 | PDE4D (0.47) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL4465297 | 0.82 | HTR2C (0.40) | HTR2CMAPTHTTLMNANPC1 | |
| SCHEMBL4328666 | 0.76 | PDE4D (0.39) | HTR2CMAPTHTTLMNANPC1 | |
| SCHEMBL1751525 | 0.76 | ALDH1A1 (0.48) | HTTLMNANPC1ALDH1A1EGFR | |
| SCHEMBL4036023 | 0.75 | PDE4A (0.57) | MAPTNPC1ALDH1A1SMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL4026672 | 0.75 | ALDH1A1 (0.47) | HTTLMNANPC1ALDH1A1EGFR | |
| SCHEMBL1750895 | 0.75 | HTT (0.43) | HTTLMNANPC1ALDH1A1EGFR | |
| SCHEMBL4033553 | 0.74 | SMN1; SMN2 (0.56) | MAPTHTTLMNANPC1ALDH1A1 | |
| SCHEMBL4326546 | 0.74 | PDE4D (0.59) | HTR2CSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | disclosed |