Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1282917 | 0.84 | ALDH1A1 (0.65) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL4330748 | 0.82 | KDM4E (0.62) | ALDH1A1TDP1TSHRMAPK1SCN5A | |
| SCHEMBL15397422 | 0.82 | ALDH1A1 (0.65) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL8408603 | 0.81 | ALDH1A1 (0.54) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL24729065 | 0.80 | ALDH1A1 (0.63) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL4064899 | 0.77 | ALDH1A1 (0.55) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL8025090 | 0.77 | ALDH1A1 (0.58) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL2875064 | 0.76 | KDM4E (0.62) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL5710874 | 0.76 | ALDH1A1 (0.65) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL4193889 | 0.76 | TSHR (0.56) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312424-A1 | AROMATIC PRODRUGS OF PROPOFOL, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2009-12-17 | — | — | US | disclosed |
| US-7576127-B2 | Aromatic prodrugs of propofol, compositions and uses thereof | XENOPORT, INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-7230003-B2 | Aromatic prodrugs of propofol, compositions and uses thereof | XENOPORT, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-20060287525-A1 | Aromatic prodrugs of propofol, compositions and uses thereof | XENOPORT, INC. | 2006-12-21 | — | — | US | disclosed |
| US-20050107385-A1 | Aromatic prodrugs of propofol, compositions and uses thereof | XENOPORT, INC. | 2005-05-19 | — | — | US | disclosed |
| WO-2005023204-A2 | AROMATIC PRODRUGS OF PROPOFOL, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312424-A1 | AROMATIC PRODRUGS OF PROPOFOL, COMPOSITIONS AND USES THEREOF | CYP2C19, CYP3A5, CYP2C9 | ALDH1A1 3668/4885TDP1 1112/4885L3MBTL1 3320/4885 |
| US-20050107385-A1 | Aromatic prodrugs of propofol, compositions and uses thereof | CYP2C19, CYP3A5, CYP2C9 | ALDH1A1 3668/4885TDP1 1112/4885L3MBTL1 3320/4885 |
| US-20060287525-A1 | Aromatic prodrugs of propofol, compositions and uses thereof | CYP2C19, CYP3A5, CYP2C9 | ALDH1A1 3668/4885TDP1 1112/4885L3MBTL1 3320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.