Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.53 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GGT1 | P19440 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1952758 | 0.82 | SCN5A (0.58) | HPGDTSHRPTGS1BLMLMNA | |
| SCHEMBL4336004 | 0.82 | ALDH1A1 (0.48) | KDM4EHSD17B10HPGDALDH1A1TSHR | |
| SCHEMBL1721235 | 0.80 | KDM4E (0.78) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| SCHEMBL4327418 | 0.80 | NPSR1 (0.52) | KDM4EHSD17B10HPGDALDH1A1MEN1 | |
| SCHEMBL4333091 | 0.80 | ALDH1A1 (0.45) | KDM4EHSD17B10ALDH1A1LMNACYP1A2 | |
| SCHEMBL47856 | 0.77 | KDM4E (1.00) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| SCHEMBL991362 | 0.77 | TSHR (0.50) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| SCHEMBL1913800 | 0.76 | KDM4E (0.72) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| SCHEMBL254364 | 0.75 | ALDH1A1 (0.59) | KDM4EHSD17B10HPGDALDH1A1HMGB1 | |
| Hydrogen Peroxide SCHEMBL9514730 | 0.75 | ALDH1A1 (0.59) | KDM4EHSD17B10HPGDALDH1A1HMGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312424-A1 | AROMATIC PRODRUGS OF PROPOFOL, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2009-12-17 | — | — | US | disclosed |
| US-7576127-B2 | Aromatic prodrugs of propofol, compositions and uses thereof | XENOPORT, INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-7230003-B2 | Aromatic prodrugs of propofol, compositions and uses thereof | XENOPORT, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-20060287525-A1 | Aromatic prodrugs of propofol, compositions and uses thereof | XENOPORT, INC. | 2006-12-21 | — | — | US | disclosed |
| US-20050107385-A1 | Aromatic prodrugs of propofol, compositions and uses thereof | XENOPORT, INC. | 2005-05-19 | — | — | US | disclosed |
| WO-2005023204-A2 | AROMATIC PRODRUGS OF PROPOFOL, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312424-A1 | AROMATIC PRODRUGS OF PROPOFOL, COMPOSITIONS AND USES THEREOF | CYP2C19, CYP3A5, CYP2C9 | KDM4E 820/4885HSD17B10 3054/4885HPGD 614/4885 |
| US-20050107385-A1 | Aromatic prodrugs of propofol, compositions and uses thereof | CYP2C19, CYP3A5, CYP2C9 | KDM4E 820/4885HSD17B10 3054/4885HPGD 614/4885 |
| US-20060287525-A1 | Aromatic prodrugs of propofol, compositions and uses thereof | CYP2C19, CYP3A5, CYP2C9 | KDM4E 820/4885HSD17B10 3054/4885HPGD 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.