Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | RAD52 | P43351 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3641050 | 0.91 | POLB (0.41) | POLBRAD52HRH3RAB9AKMT2A | |
| SCHEMBL6096807 | 0.89 | HTR1A (0.51) | POLBRAD52HRH3SLC2A1BCHE | |
| SCHEMBL7218710 | 0.87 | POLB (0.45) | POLBRAD52HRH3RAB9AKMT2A | |
| SCHEMBL6787115 | 0.85 | HRH3 (0.45) | POLBRAD52HRH3RAB9AKMT2A | |
| SCHEMBL5118839 | 0.85 | S1PR2 (0.49) | POLBRAD52HRH3RAB9AKMT2A | |
| SCHEMBL10728537 | 0.85 | POLB (0.63) | POLBRAD52HRH3RAB9AKMT2A | |
| SCHEMBL4313700 | 0.84 | POLB (0.57) | POLBRAD52HRH3RAB9AKMT2A | |
| SCHEMBL10589295 | 0.83 | S1PR2 (0.57) | POLBRAD52HRH3RAB9AKMT2A | |
| SCHEMBL9602243 | 0.83 | S1PR2 (0.57) | POLBRAD52HRH3RAB9AKMT2A | |
| SCHEMBL31197371 | 0.83 | S1PR2 (0.57) | POLBRAD52HRH3RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908880-B2 | Substituted imidazoquinolines | 4SC AG (DE) | 2018-03-06 | — | — | US | disclosed |
| EP-2386557-B1 | Novel substituted imidazoquinolines | 4SC DISCOVERY GMBH (DE) | 2018-01-10 | — | — | EP | disclosed |
| US-20170029422-A1 | NOVEL SUBSTITUTED IMIDAZOQUINOLINES | 4SC AG (DE) | 2017-02-02 | — | — | US | disclosed |
| EP-2276486-B1 | NOVEL SUBSTITUTED IMIDAZOQUINOLINES | 4SC DISCOVERY GMBH (DE) | 2013-08-28 | — | — | EP | disclosed |
| WO-2009118296-A2 | NOVEL SUBSTITUTED IMIDAZOQUINOLINES | 4SC AG (DE) | 2009-10-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029422-A1 | NOVEL SUBSTITUTED IMIDAZOQUINOLINES | TLR7, TLR1, TLR4 | POLB 2631/4885RAD52 1019/4885HRH3 445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.