Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4336653 | 0.92 | KDM4E (0.64) | KDM4EGAATSHRPOLBMEN1 | |
| Phenol SCHEMBL4337824 | 0.87 | KDM4E (0.55) | KDM4EGAATSHRPOLBMEN1 | |
| Phenol SCHEMBL4337822 | 0.83 | KDM4E (0.58) | KDM4EGAATSHRPOLBMEN1 | |
| SCHEMBL12528207 | 0.82 | KDM4E (0.65) | KDM4EGAATSHRPOLBMEN1 | |
| SCHEMBL17033294 | 0.82 | KDM4E (0.58) | KDM4EGAATSHRPOLBMEN1 | |
| SCHEMBL2052349 | 0.82 | KDM4E (0.67) | KDM4EGAATSHRCA12CA1 | |
| Hydrochloric Acid SCHEMBL4340038 | 0.82 | KDM4E (0.50) | KDM4EGAATSHRCA12CA1 | |
| SCHEMBL27993628 | 0.82 | KDM4E (0.50) | KDM4EGAATSHRCA12CA1 | |
| SCHEMBL6174610 | 0.80 | MEN1 (0.56) | KDM4EGAATSHRPOLBMEN1 | |
| SCHEMBL1956516 | 0.78 | KDM4E (0.54) | KDM4EGAATSHRCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9082989-B2 | Platinum (II) di (2-pyrazolyl) benzene chloride analogs and uses | Arizona Board of Regents for and on behalf of Arizona State Univesity (US) | 2015-07-14 | — | — | US | disclosed |
| US-8846940-B2 | Platinum (II) di (2-pyrazolyl) benzene chloride analogs and uses | ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2014-09-30 | — | — | US | disclosed |
| US-20140066628-A1 | Platinum (II) Di (2-Pyrazolyl) Benzene Chloride Analogs and Uses | ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2014-03-06 | — | — | US | disclosed |
| US-20110301351-A1 | Platinum (II) Di (2-Pyrazolyl) Benzene Chloride Analogs and Uses | ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2011-12-08 | — | — | US | disclosed |
| WO-2009086209-A2 | PLATINUM(II) DI(2-PYRAZOLYL)BENZENE CHLORIDE ANALOGS AND USES | ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301351-A1 | Platinum (II) Di (2-Pyrazolyl) Benzene Chloride Analogs and Uses | PDCD1LG2, PDCD2L, IDH1 | KDM4E 3941/4885GAA 4558/4885TSHR 2927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.