Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4336653 | 0.87 | KDM4E (0.64) | KDM4EGAATSHRTDP1POLB | |
| Hydrochloric Acid SCHEMBL4336655 | 0.83 | KDM4E (0.64) | KDM4EGAATSHRTDP1POLB | |
| SCHEMBL2052349 | 0.82 | KDM4E (0.67) | KDM4EGAATSHRTDP1POLB | |
| Bicarbonate SCHEMBL17255684 | 0.80 | KDM4E (0.59) | KDM4EGAATSHRTDP1POLB | |
| Phenol SCHEMBL4337824 | 0.79 | KDM4E (0.55) | KDM4EGAATSHRTDP1POLB | |
| SCHEMBL17255696 | 0.76 | KDM4E (0.58) | KDM4EGAATSHRMAPTHSD17B10 | |
| SCHEMBL17255679 | 0.76 | KDM4E (0.62) | KDM4EGAATSHRMAPTMAPK1 | |
| SCHEMBL17033294 | 0.75 | KDM4E (0.58) | KDM4EGAATSHRTDP1POLB | |
| SCHEMBL12528207 | 0.75 | KDM4E (0.65) | KDM4EGAATSHRTDP1POLB | |
| SCHEMBL597831 | 0.74 | MAPT (0.57) | KDM4EGAATDP1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9082989-B2 | Platinum (II) di (2-pyrazolyl) benzene chloride analogs and uses | Arizona Board of Regents for and on behalf of Arizona State Univesity (US) | 2015-07-14 | — | — | US | disclosed |
| US-8846940-B2 | Platinum (II) di (2-pyrazolyl) benzene chloride analogs and uses | ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2014-09-30 | — | — | US | disclosed |
| US-20140066628-A1 | Platinum (II) Di (2-Pyrazolyl) Benzene Chloride Analogs and Uses | ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2014-03-06 | — | — | US | disclosed |
| US-20110301351-A1 | Platinum (II) Di (2-Pyrazolyl) Benzene Chloride Analogs and Uses | ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2011-12-08 | — | — | US | disclosed |
| WO-2009086209-A2 | PLATINUM(II) DI(2-PYRAZOLYL)BENZENE CHLORIDE ANALOGS AND USES | ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301351-A1 | Platinum (II) Di (2-Pyrazolyl) Benzene Chloride Analogs and Uses | PDCD1LG2, PDCD2L, IDH1 | KDM4E 3941/4885GAA 4558/4885TSHR 2927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.