Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2076431 | 0.74 | SLC6A2 (0.40) | MAPTGAARAB9ANPC1 | |
| SCHEMBL6888843 | 0.74 | ALDH1A1 (0.44) | MAPTPOLBKDM4EHPGDALDH1A1 | |
| SCHEMBL12109783 | 0.72 | ALDH1A1 (0.40) | MAPTPOLBKDM4EHPGDALDH1A1 | |
| SCHEMBL1607217 | 0.71 | MEN1 (0.41) | POLBKDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL28413241 | 0.71 | ALDH1A1 (0.42) | MAPTPOLBKDM4EHPGDALDH1A1 | |
| SCHEMBL13062631 | 0.69 | SCN10A (0.47) | MAPTPOLBKDM4EHPGDALDH1A1 | |
| SCHEMBL3825216 | 0.68 | CYP2A6 (0.36) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4798408 | 0.68 | MLKL (0.43) | KDM4EHPGDALDH1A1RAB9AMEN1 | |
| SCHEMBL24630921 | 0.68 | ADRB2 (0.48) | KDM4EKMT2ASMN1; SMN2TDP1 | |
| SCHEMBL4393880 | 0.67 | MAPT (0.50) | MAPTPOLBKDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569688-B2 | Propane-1, 3-dione derivative | ASTELLAS PHARMA INC. (JP) | 2009-08-04 | — | — | US | disclosed |
| EP-1300398-B1 | PROPANE-1,3-DIONE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2006-04-05 | — | — | EP | disclosed |
| US-20050267110-A1 | Propane-1, 3-dione derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. | 2005-12-01 | — | — | US | disclosed |
| US-6960591-B2 | Propane-1,3-dione derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-20030191164-A1 | Propane-1,3-dione derivatives | ASTELLAS PHARMA INC. (JP) | 2003-10-09 | — | — | US | disclosed |
| EP-1300398-A1 | PROPANE-1,3-DIONE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2003-04-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191164-A1 | Propane-1,3-dione derivatives | GNRHR, GPER1, FSHR | MAPT 2864/4885POLB 2132/4885KDM4E 2229/4885 |
| US-20050267110-A1 | Propane-1, 3-dione derivative | GNRHR, GPER1, FSHR | MAPT 3016/4885POLB 2186/4885KDM4E 2190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.