SCHEMBL4338019

SCHEMBL4338019

Cc1nc(NC(=O)c2ccccc2OC(F)(F)F)sc1C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.57
NPC1 O15118 6/20 0.57
ALDH1A1 P00352 5/20 0.57
SMN1; SMN2 Q16637 4/20 0.57
KDM4E B2RXH2 1/20 0.57
HPGD P15428 1/20 0.57
PKM P14618 4/20 0.55
TP53 P04637 2/20 0.55
ALOX15 P16050 1/20 0.55
HTT P42858 1/20 0.55
HSD17B10 Q99714 1/20 0.55
TDP1 Q9NUW8 1/20 0.52
NPSR1 Q6W5P4 1/20 0.51
PDE5A O76074 1/20 0.49
PDE1A P54750 1/20 0.49
PDE1B Q01064 1/20 0.49
PDE1C Q14123 1/20 0.49
KCNK3 O14649 4/20 0.49
KCNK9 Q9NPC2 4/20 0.49
MEN1 O00255 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3588472 0.87 SCD (0.61) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL28773979 0.86 NPC1 (0.49) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL4184590 0.82 RAB9A (0.58) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL3585640 0.81 RAB9A (0.81) RAB9ANPC1ALDH1A1SMN1; SMN2PKM
SCHEMBL3584894 0.80 RAB9A (0.80) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL4196070 0.80 NPC1 (0.61) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL4187271 0.78 RAB9A (0.56) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL29949369 0.78 MAPT (0.53) RAB9ANPC1ALDH1A1PKMTP53
SCHEMBL4196428 0.77 SMN1; SMN2 (0.81) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL16766930 0.77 MAPT (0.52) RAB9ANPC1TP53KCNK3KCNK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2029138-A1 AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS XENON PHARMACEUTICALS INC. (CA) 2009-03-04 EP disclosed
WO-2007130075-A1 AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS XENON PHARMACEUTICALS INC. (CA) 2007-11-15 WO disclosed