Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 2/20 | 0.44 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.41 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.41 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.41 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13578227 | 0.94 | PHGDH (0.48) | PHGDHGUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| Trifluoroacetic Acid SCHEMBL4330430 | 0.84 | CASP3 (0.46) | PHGDHMAPK1TACR3PDE2A | |
| Trifluoroacetic Acid SCHEMBL4320255 | 0.84 | CASP3 (0.46) | PHGDHMAPK1TACR3PDE2A | |
| Trifluoroacetic Acid SCHEMBL4326405 | 0.83 | HMGCR (0.45) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL4329955 | 0.81 | CNR2 (0.49) | HAT1EP300 | |
| Trifluoroacetic Acid SCHEMBL4333546 | 0.81 | CNR2 (0.49) | HAT1EP300 | |
| Trifluoroacetic Acid SCHEMBL4341766 | 0.81 | CNR2 (0.55) | — | |
| Trifluoroacetic Acid SCHEMBL4329810 | 0.79 | CNR2 (0.56) | MAPK1TACR3 | |
| Trifluoroacetic Acid SCHEMBL4328508 | 0.78 | PDE2A (0.38) | ROCK2MAPK1ROCK1PDE2A | |
| SCHEMBL13578204 | 0.77 | HMGCR (0.46) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325936-A1 | IMIDAZOPYRIDINE ANALOGS AS CB2 RECEPTOR MODULATORS, USEFUL IN THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES | MERCK & CO., INC. | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325936-A1 | IMIDAZOPYRIDINE ANALOGS AS CB2 RECEPTOR MODULATORS, USEFUL IN THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES | CNR2, CNR1, TRPV1 | PHGDH 2689/4885GUCY1B2 1139/4885GUCY1A2 1180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.